N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride
Synonym(s):N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulphonamide dihydrochloride
- CAS NO.：1177141-67-1
- Empirical Formula: C11H14Cl3N3O2S
- Molecular Weight: 358.67176
- MDL number: MFCD00897689
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-09-10 08:17:50
What is N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride?
Chemical properties
Beige Solid
The Uses of N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride
Found to have a potent inhibitory action against casein kinase 1 completely with respect to ATP and a much weaker effect on casein kinase 2 and other protein kinases
What are the applications of Application
CKI-7 dihydrochloride is an inhibitor of CK1, SGK, p70 S6 Kinase (S6K1) and MSK1.
Biochem/physiol Actions
CKI-7 is a CK1 inhibitor; also inhibits SGK, S6K1 and MSK1. CKI-7 inhibits SGK as potently as CK1. IC50 = 6 μM.
Storage
Store at -20°C
Properties of N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride
| Melting point: | 187-189°C |
| storage temp. | -20°C |
| solubility | H2O: >5mg/mL |
| form | solid |
| color | white to light tan |
Safety information for N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral |
| Precautionary Statement Codes |
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
Computed Descriptors for N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride
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