MYXOTHIAZOL
Synonym(s):Myxothiazol A
- CAS NO.：76706-55-3
- Empirical Formula: C25H33N3O3S2
- Molecular Weight: 487.68
- MDL number: MFCD00043397
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:13:23
What is MYXOTHIAZOL?
The Uses of MYXOTHIAZOL
Myxothiazol has been used in as a mitochondrial electron transport chain (mETC) inhibitor in P19 murine embryonal carcinoma pluripotent cell line and to treat HeLa cells for integrated stress response activation.
Definition
ChEBI: A 2,4'-bi-1,3-thiazole substituted at the 4-position with a (1E,3S,4R,5E)-7-amino-3,5-dimethoxy-4-methyl-7-oxohepta-1,5-dien-1-yl] group and at the 2'-position with a (2S
Biochem/physiol Actions
Myxothiazol, an antibiotic with activity against fungi and insects, is a strong inhibitor of mitochondrial cytochrome b/c1-segment of respiratory chain. Myxothiazol binds to the quinol oxidation (Qo) site of the bc1 complex, blocking electron transfer to the Rieske iron-sulfur protein in the mitochondrial respiratory chain. Oxygen consumption blockage leads to a cytostatic effect that could be reversed. Myxothiazol, as other Epothilones, which are known for their anti tumor activity, contains a thiazole ring that is formed by the incorporation of cysteine into the polyketide backbone.
Properties of MYXOTHIAZOL
| Boiling point: | 679.6±65.0 °C(Predicted) |
| Density | 1.158±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | chloroform: soluble9.80 - 10.20mg/mL, clear, colorless to yellow |
| form | Solid |
| pka | 14.07±0.50(Predicted) |
| color | White to off-white |
Safety information for MYXOTHIAZOL
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H300:Acute toxicity,oral |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P405:Store locked up. P501:Dispose of contents/container to..… |
Computed Descriptors for MYXOTHIAZOL
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