Mubritinib
Synonym(s):(E)-4-((4-(4-(1H-1,2,3-triazol-1-yl)butyl)phenoxy)methyl)-2-(4-(trifluoromethyl)styryl)oxazole;1-[4-[4-[[2-[(1E)-2-[4-(Trifluoromethyl)phenyl]ethenyl]-4-oxazolyl]methoxy]phenyl]butyl]-1H-1,2,3-triazole;CID 6444692;TAK 165;TAK-165
- CAS NO.：366017-09-6
- Empirical Formula: C25H23F3N4O2
- Molecular Weight: 468.47
- MDL number: MFCD09954135
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:13:43
What is Mubritinib?
The Uses of Mubritinib
Mubritinib is used in selective targeting of CTNNB1-, KRAS-or MYC-driven human cancer cell growth by combinations of existing drugs
The Uses of Mubritinib
Treatment of cancer.
What are the applications of Application
TAK 165 is a selective, potent, and irreversible ErbB2 and EGFR inhibitor
Biological Activity
Potent, irreversible human epithelial growth factor receptor 2 (ErbB2) inhibitor (IC 50 = 6 nM) that displays > 4000-fold selectivity over EGFR, FGFR, PDGFR, JAK1 and Src. Exhibits potent antiproliferative effects in ErbB2-overexpressing cancer cell lines (IC 50 = 5 nM in BT474 breast cancer cells) and significantly inhibits bladder, breast and prostate cancer xenograft growth in vivo .
Storage
Store at +4°C
Properties of Mubritinib
| Melting point: | 158.0 to 162.0 °C |
| Boiling point: | 620.9±65.0 °C(Predicted) |
| Density | 1.25±0.1 g/cm3(Predicted) |
| storage temp. | Store at +4°C |
| solubility | DMSO : 50 mg/mL (106.73 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble) |
| pka | 1.45±0.10(Predicted) |
| form | powder to crystal |
| color | White to Gray to Brown |
Safety information for Mubritinib
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H320:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Mubritinib
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