Montelukast sodium
Synonym(s):1-[[[(1R)-1-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid sodium salt hydrate;Montelukast sodium
- CAS NO.:151767-02-1
- Empirical Formula: C35H37ClNNaO3S
- Molecular Weight: 610.18
- MDL number: MFCD00931431
- EINECS: 604-813-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-06-06 17:55:34
![Montelukast sodium Structural](https://img.chemicalbook.in/CAS/GIF/151767-02-1.gif)
What is Montelukast sodium?
Description
Montelukast is a potent, selective and orally active antagonist of the CysLT1 (formerly called LTD4) receptor, thus blocking the effects of the cysteinyl leukotrienes LTC4, LTD4 and LTE4 on microvascular permeability and the activation of eosinophils. Montelukast represents the third molecule of this class which has been approved in asthma after pranlukast (1995) and zafirlukast (1996).
The Uses of Montelukast sodium
Montelukast sodium hydrate has been used as a positive control drug to study the protective effects of Gumiganghwal-tang aqueous extract (GGTA) against airway inflammation and pulmonary fibrosis.
The Uses of Montelukast sodium
Montelukast Sodium is a potent and highly selective CysLT1 receptor antagonist, without demonstrated CysLT2 activity. It was launched to moderate asthma inadequately controlled by inhaled corticosteroids and short-acting beta2-agonists.
Properties of Montelukast sodium
Melting point: | 115 °C(dec.) |
storage temp. | 2-8°C |
solubility | DMSO: ≥8mg/mL at 60°C |
form | powder |
color | white to tan |
Safety information for Montelukast sodium
Signal word | Danger |
Pictogram(s) |
![]() Corrosion Corrosives GHS05 ![]() Health Hazard GHS08 |
GHS Hazard Statements |
H318:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for Montelukast sodium
InChIKey | LBFBRXGCXUHRJY-HKHDRNBDSA-M |
Abamectin manufacturer
Chynops Pharma
Dr. Reddy's Laboratories Ltd
SNECOFRi PVT LTD
SUPREME DRUGS PVT LTD
Vadivarhe Speciality Chemicals Limited
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