MMP-8 INHIBITOR I

CAS NO.：236403-25-1
Empirical Formula: C17H18N2O5S
Molecular Weight: 362.4
MDL number: MFCD02683950
Update Date: 2026-04-24 14:58:30

What is MMP-8 INHIBITOR I?

Description

MMP-8 Inhibitor I is a selective inhibitor of the neutrophil collagenase matrix metalloproteinase-8 (MMP-8) with an IC₅₀ value of 4 nM. This inhibitor does not target the activities of other MMPs in vitro. MMP-8 cleaves interstitial collagens and has exhibited activity in atherosclerotic plaques, angiogenesis, and stem cell mobilization. Additionally, MMP-8 expression is observed in normal mammary epithelial cells, whereas a loss of expression is observed in human ductal carcinoma in situ and the deletion of MMP-8 accelerates tumor onset in a mouse model of aggressive breast cancer.

The Uses of MMP-8 INHIBITOR I

MMP 8-I is a matrix metalloproteinase 8 inhibitor. Matrix metalloproteinases are involved with tight junction protein degradation in endothelial cells.

What are the applications of Application

MMP-8 Inhibitor I is a potent, cell-permeable MMP-8 inhibitor

Properties of MMP-8 INHIBITOR I

storage temp.	-20°C
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
color	Off-White to Light Yellow

Safety information for MMP-8 INHIBITOR I

Computed Descriptors for MMP-8 INHIBITOR I

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