ML329

CAS NO.：19992-50-8
Empirical Formula: C16H12N2O4S
Molecular Weight: 328.34
MDL number: MFCD30579194
EINECS: 604-604-1
SAFETY DATA SHEET (SDS)
Update Date: 2025-12-07 19:09:50

What is ML329?

Definition

ChEBI: 4-[(1,4-dioxo-2-naphthalenyl)amino]benzenesulfonamide is a member of 1,4-naphthoquinones.

Biological Activity

ML329 is a micropthalmia-associated transcription factor (MITF) inhibitor that inhibits TRPM-1 promoter activity with IC50 of 1.2 μM.

in vitro

ML329 inhibits the expression of numerous micropthalmia-associated transcription factor (MITF) target genes and blocks the proliferation of numerous cell lines that require MITF for proliferation. It could directly or indirectly interact with MITF or components of the MITF regulatory network. As a transcription factor that regulates cell cycle and pigmentation, interference of MITF with it will be useful in characterizing the specific roles of MITF in melanoma and validate blockade of MITF function as a potential treatment of melanoma. It shows specific activity against the MITF -dependent cells, primary melanocytes but no effect on the viability in A375 cells. It reduces the expression of multiple MITF target genes, including pigment-related genes and the cell cycle regulator CDK2. As a tool compound, it will be useful in elucidating the role of MITF in melanocyte lineage development and in melanoma disease progression.

Properties of ML329

storage temp.	2-8°C(protect from light)
solubility	DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 0.1 mg/ml
form	A crystalline solid
color	White to off-white

Safety information for ML329

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.