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Home Product name listML-180

ML-180

CAS NO.：863588-32-3
Empirical Formula: C20H25ClN4O2
Molecular Weight: 388.89
MDL number: MFCD05894342
SAFETY DATA SHEET (SDS)
Update Date: 2026-03-13 23:13:44

ML-180 Structural

What is ML-180?

Description

ML-180 is an inverse agonist of liver receptor homolog-1 (LRH-1, IC₅₀ = 3.7 μM) with maximum efficacy of 64% repression. It is inactive at the related steroidogenic factor-1 transcriptional activator. Through LRH-1, ML-180 alters the expression of haptoglobin and serum amyloid proteins A1 and A4, induces the death of estrogen-receptor negative MDA-MB-231 breast cancer cells, and inhibits the steroidogenic acute regulatory promoter (IC₅₀ = 2.05 μM).

What are the applications of Application

ML-180 is an antagonist for LRH1 (NR5A2)

Definition

ChEBI: 6-[4-(3-chlorophenyl)-1-piperazinyl]-3-cyclohexyl-1H-pyrimidine-2,4-dione is a member of piperazines.

Properties of ML-180

Density	1.312±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: 10 mg/ml
form	A crystalline solid
pka	9.37±0.40(Predicted)
color	Off-white to light yellow

Safety information for ML-180

Computed Descriptors for ML-180

New Products

Mirtazapine Impurity C/Mirtazapine Lactam Impurity Cyclopropane-1,1-dicarboxylic acid [1]Benzothieno[2,3-c]pyridine, 1,7-dichloro-8-methyl- (S)-3-Fluoro-pyrrolidine hydrochloride Cyclobutylamine 1-Bromo-2-Methoxy-3-Nitrobenzene 3-Oxocyclobutane-1-carboxylicacid (4-Bromophenyl)(3,4-dimethoxyphenyl)methanone N-Nitroso hydroxy Cetrizine EP Impurity-A Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity Lantanoprost rc B Clidinium Bromide Impurity 2-chloro-7-cyclopentyl-N,N-dimethylpyrrolo [2,3-d]pyrimidine-6-carbox amide 4-amino-2-fluoro-N- methylbenzamide N-(2-chloropyrimidin-4-yl)-N,2,3- trimethyl-2H- indazol 6-amine 5-Chloro-3- Methyl -1,3-2-benzoxazol-2(3H)-one 4-Bromo-2-fluoro-N-methylbenzamide N-Boc-1,4-butanediamine 4-Dimethylamino pyridine 2-Chlorotrityl Chloride 4-Bromoaniline 5-Bromo-2-chlorobenzoic acid 1,2,3,9-Tetrahydro-4(H)-carbazol-4-one

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N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine

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[4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone

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