Misoprostol Acid

CAS NO.：112137-89-0
Empirical Formula: C21H36O5
Molecular Weight: 368.51
MDL number: MFCD07772001
SAFETY DATA SHEET (SDS)
Update Date: 2026-03-13 09:27:42

What is Misoprostol Acid ?

Description

Misoprostol is a prostaglandin E₁ analog with agonist activity mediated by EP₂, EP₃, and EP₄ receptors. It has been shown to inhibit the formation of gastric lesions in rats (ED₅₀ = 0.31 μg/kg), inhibit superoxide generation in human neutrophils (EC₅₀ = 0.35 μM), and relax fetal rabbit ductus arteriosus (EC₅₀ = 0.36 nM) in a concentration dependent manner. Misoprostol is commonly used in clinical medicine for the prevention of peptic ulcer disease. It has also been used in conjunction with mifepristone (RU-486; ) for the oral induction of first trimester abortion. Misoprostol contains a C-1 methyl ester and is readily absorbed and rapidly hydrolyzed in humans to the active free acid.

Chemical properties

Pale Yellow Gel

The Uses of Misoprostol Acid

Misoprostol Acid is a prostaglandin E1 analog with agonist activity mediated by EP2, EP3, and EP4 receptors. It has been shown to inhibit the formation of gastric lesions in rats (ED50 = 0.31 μg/kg), inhibit superoxide generation in human neutrophils (EC50 = 0.35 μM), and relax fetal rabbit ductus arteriosus (EC50 = 0.36 nM) in a concentration dependent manner. Misoprostol is commonly used in clinical medicine for the prevention of peptic ulcer disease. It has also been used in conjunction with mifepristone (RU-486; ) for the oral induction of first trimester abortion. Misoprostol contains a C-1 methyl ester and is readily absorbed and rapidly hydrolyzed in humans to the active free acid.

The Uses of Misoprostol Acid

A metabolite of Misoprostol. Cytoprotective PGE1 analog that prevents NSAID-induced gastric ulceration

The Uses of Misoprostol Acid

A cytoprotective prostaglandin PGE1 analogue.

What are the applications of Application

Misoprostol (free acid) is a PGE1 analog with agonist activity mediated by EP2, EP3, and EP4 receptors

Biochem/physiol Actions

Misoprostol is a synthetic prostaglandin E1 (PGE1) analogue use to prevent non steroidal anti inflammatory drug-induced (NSAID) gastric ulcers; as a labor inducing and postpartum hemorrhage treatment agent.

Properties of Misoprostol Acid

Boiling point:	538.3±50.0 °C(Predicted)
Density	1.118±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	Chloroform
form	Yellow viscous oil.
pka	4.77±0.10(Predicted)
color	Pale Yellow
Stability:	Temperature Sensitive

Safety information for Misoprostol Acid

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08
GHS Hazard Statements	H301:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H361:Reproductive toxicity
Precautionary Statement Codes	P201:Obtain special instructions before use. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.