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HomeProduct name list15(R)-PROSTAGLANDIN E1

15(R)-PROSTAGLANDIN E1

15(R)-PROSTAGLANDIN E1 Structural

What is 15(R)-PROSTAGLANDIN E1?

Description

13,14-dihydro Prostaglandin E1 (13,14-dihydro PGE1) is a biologically active metabolite of PGE1 with comparable potency to the parent compound. It is an inhibitor of ADP-induced platelet aggregation in human PRP and washed platelets with IC50 values of 31 and 21 nM, respectively. 13,14-dihydro PGE1 is a slightly more potent inhibitor of ADP-induced human platelet aggregation than PGE1 which has an IC50 value of 40 nM. Also, 13,14-dihydro PGE1 was shown to activate adenylate cyclase in NCB-20 hybrid cells with a Kact value of 668 nM.

The Uses of 15(R)-PROSTAGLANDIN E1

Prostaglandin E0 is a metabolite of Prostaglandin E1 (P838600) and can inhibit aggregation, ATP release, and thromboxane generation by human platelets. Prostaglandin E0 can also decrease the formation of cyclooxygenase (COX) metabolites by inhibiting the induction of COX-2 protein by LPS.

What are the applications of Application

13,14-Dihydro-prostaglandin E1 (PGE0) is a PGE1 metabolite that inhibits platelet aggregation & shows antimitotic activity

Definition

ChEBI: 13,14-Dihydro PGE1 is a prostanoid.

Properties of 15(R)-PROSTAGLANDIN E1

Boiling point: 541.4±35.0 °C(Predicted)
Density  1.075±0.06 g/cm3(Predicted)
storage temp.  Refrigerator, under inert atmosphere
solubility  Ethyl Acetate, Methanol, Tetrahydrofuran
form  Colorless to pale yellow oil
pka 4.77±0.10(Predicted)
Stability: Volatile

Safety information for 15(R)-PROSTAGLANDIN E1

Computed Descriptors for 15(R)-PROSTAGLANDIN E1

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