15(R)-PROSTAGLANDIN E1

CAS NO.：19313-28-1
Empirical Formula: C20H36O5
Molecular Weight: 356.5
MDL number: MFCD00135208
SAFETY DATA SHEET (SDS)
Update Date: 2026-03-13 09:27:42

What is 15(R)-PROSTAGLANDIN E1?

Description

13,14-dihydro Prostaglandin E₁ (13,14-dihydro PGE₁) is a biologically active metabolite of PGE₁ with comparable potency to the parent compound. It is an inhibitor of ADP-induced platelet aggregation in human PRP and washed platelets with IC₅₀ values of 31 and 21 nM, respectively. 13,14-dihydro PGE₁ is a slightly more potent inhibitor of ADP-induced human platelet aggregation than PGE₁ which has an IC₅₀ value of 40 nM. Also, 13,14-dihydro PGE₁ was shown to activate adenylate cyclase in NCB-20 hybrid cells with a K_act value of 668 nM.

The Uses of 15(R)-PROSTAGLANDIN E1

Prostaglandin E0 is a metabolite of Prostaglandin E1 (P838600) and can inhibit aggregation, ATP release, and thromboxane generation by human platelets. Prostaglandin E0 can also decrease the formation of cyclooxygenase (COX) metabolites by inhibiting the induction of COX-2 protein by LPS.

What are the applications of Application

13,14-Dihydro-prostaglandin E1 (PGE0) is a PGE1 metabolite that inhibits platelet aggregation & shows antimitotic activity

Definition

ChEBI: 13,14-Dihydro PGE1 is a prostanoid.

Properties of 15(R)-PROSTAGLANDIN E1

Boiling point:	541.4±35.0 °C(Predicted)
Density	1.075±0.06 g/cm3(Predicted)
storage temp.	Refrigerator, under inert atmosphere
solubility	Ethyl Acetate, Methanol, Tetrahydrofuran
form	Colorless to pale yellow oil
pka	4.77±0.10(Predicted)
Stability:	Volatile