MI-3 (Menin-MLL Inhibitor)
- CAS NO.：1271738-59-0
- Empirical Formula: C18H25N5S2
- Molecular Weight: 375.55
- MDL number: MFCD28348362
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-12 09:17:10
What is MI-3 (Menin-MLL Inhibitor)?
Description
MI-3 is an inhibitor of the interaction between menin and mixed lineage leukemia (MLL) fusion proteins (IC50 = 648 nM). MI-3 binds to menin (Kd = 201 nM) and inhibits the menin interaction with the MLL fusion protein MLL-AF9 in HEK293 cells without affecting protein levels of menin or MLL-AF9. It inhibits growth of mouse bone marrow cells (BMCs) expressing the Hoxa9 transformation-dependent MLL fusion proteins MLL-AF9 or MLL-ENL (IC50 = 5 μM for both), as well as reduces colony formation and induces differentiation of MLL-AF9-transformed BMCs. MI-3 inhibits growth of human leukemia cell lines containing MLL translocations and decreases the expression of the transcription factors HOXA9, HOXA10, and MEIS1 in THP-1 cells.
The Uses of MI-3 (Menin-MLL Inhibitor)
MI-3 (Menin-MLL Inhibitor) reverses oncogenic activity of MLL fusion proteins in leukemia.
Properties of MI-3 (Menin-MLL Inhibitor)
| Boiling point: | 527.9±60.0 °C(Predicted) |
| Density | 1.36±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : 8.33 mg/mL (22.18 mM; Need ultrasonic) |
| form | Powder |
| pka | 9.59±0.40(Predicted) |
| color | Light yellow to yellow |
Safety information for MI-3 (Menin-MLL Inhibitor)
Computed Descriptors for MI-3 (Menin-MLL Inhibitor)
New Products
3-AMINO-3-(2-FLUORO-PHENYL)-PROPIONIC ACID Pentadecanoic acid Hendecanoic acid 2-AMINO-3-METHYLQUINOLINE HYDROCHLORIDE 3-Hydroxypropionitrile DL-3-Amino-3-(2-methoxyphenyl)propionic acid 5-Bromo-2-Fluoropyridine 2,3-Diamino-5-Chloropyridine 2-Amino-3-Hydroxypyridine 2,6-Diamino Pyridine 4-Amino-2-Chloropyridine 2-Hydroxy-4-Picoline 4-(4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile 4-Bromo-3-(ethoxymethyl)benzoic acid 2,4-Dichloro-5-methoxyaniline 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine N2-Isobutyryl-2'-O-methylguanosine 2-chloro-5-methylpyridin-4-amine 4-Bromobenzaldehyde 2-Chloro-6-nitro benzothiazole 2-Amino-4-phenyl-thiazole 4-Chloro-2-methyl quinoline 2-(Chloromethyl) quinazolin-4(3H)-one 5-Phenyl-[1,3,4]-thiadiazol-2-amineRelated products of tetrahydrofuran
![(2R,3R,4S,5R)-2-(6-aMino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]iMidazol-2-yl)ethyl)cyclobutyl)(isopropyl)aMino)Methyl)tetrahydrofuran-3,4-diol](https://img.chemicalbook.in/CAS/20150408/GIF/1380288-87-8.gif)
You may like
-
2-Bromo-4-nitropyridine-N-oxide 52092-43-0 98%View Details
52092-43-0 -
18979-61-8 98%View Details
18979-61-8 -
4, 4'-Ditolylamine (or) 4,4-Dimethyl Diphenylamine 620-93-9 98%View Details
620-93-9 -
2-Bromo-5-Chloropyridine 98%View Details
40473-01-6 -
2-Picolinic acid N-oxide 824-40-8 98%View Details
824-40-8 -
15862-34-7 5-Bromo-2-Hydroxy-3-Nitro Pyridine 98%View Details
15862-34-7 -
2-(2,4-Diaminophenoxy)ethanol Dihydrochloride 98%View Details
66422-95-5 -
Eperisone Hydrochloride APIView Details
56839-43-1