METHYL (TRIMETHYLSILYL)ACETATE
- CAS NO.：2916-76-9
- Empirical Formula: C6H14O2Si
- Molecular Weight: 146.26
- MDL number: MFCD00008450
- EINECS: 220-845-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:25:25
What is METHYL (TRIMETHYLSILYL)ACETATE?
Chemical properties
CLEAR COLOURLESS LIQUID
The Uses of METHYL (TRIMETHYLSILYL)ACETATE
Methyl 2-(Trimethylsilyl)acetate is a useful compound in the organic synthesis.
General Description
Methyl trimethylsilylacetate on reaction with lithium diisopropylamide in THF at -78°C yields methyl lithiotrimethylsilylacetate. It also undergoes Peterson olefination to yield mainly Z-isomers of steroid 17β-side chain methyl acrylates.
Purification Methods
Methyl trimethylsilylacetate [2916-76-9] M 146.3, b 65-68o/50mm, d 4 0.89. Dissolve it in Et2O, shaken with 1M HCl, wash with H2O, aqueous saturated NaHCO3, H2O again, and dry it (a precipitate may be formed in the NaHCO3 solution and should be drawn off and discarded). The solvent is distilled off, and the residue is fractionated through a good column. IR (CHCl3) max 1728cm1 . [Fessenden & Fessenden J Org Chem 32 3535 1967, Matsuda et al. J Org Chem 45 237 1980, Beilstein 4 III 1855, 4 IV 3974 for Et ester.]
Properties of METHYL (TRIMETHYLSILYL)ACETATE
| Boiling point: | 38-39 °C13 mm Hg(lit.) |
| Density | 0.891 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | 91 °F |
| storage temp. | Flammables area |
| Specific Gravity | 0.890 |
| Hydrolytic Sensitivity | 2: reacts with aqueous acid |
| BRN | 1098961 |
Safety information for METHYL (TRIMETHYLSILYL)ACETATE
| Signal word | Warning |
| Pictogram(s) |
 Flame Flammables GHS02  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H226:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for METHYL (TRIMETHYLSILYL)ACETATE
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