Methyl (trimethylsilyl)acetate

CAS NO.：2916-76-9
Empirical Formula: C6H14O2Si
Molecular Weight: 146.26
MDL number: MFCD00008450
EINECS: 220-845-0
SAFETY DATA SHEET (SDS)
Update Date: 2026-09-12 18:55:05

What is Methyl (trimethylsilyl)acetate?

Chemical properties

CLEAR COLOURLESS LIQUID

The Uses of Methyl (trimethylsilyl)acetate

Methyl 2-(Trimethylsilyl)acetate is a useful compound in the organic synthesis.

General Description

Methyl trimethylsilylacetate on reaction with lithium diisopropylamide in THF at -78°C yields methyl lithiotrimethylsilylacetate. It also undergoes Peterson olefination to yield mainly Z-isomers of steroid 17β-side chain methyl acrylates.

Purification Methods

Methyl trimethylsilylacetate [2916-76-9] M 146.3, b 65-68o/50mm, d 4 0.89. Dissolve it in Et2O, shaken with 1M HCl, wash with H2O, aqueous saturated NaHCO3, H2O again, and dry it (a precipitate may be formed in the NaHCO3 solution and should be drawn off and discarded). The solvent is distilled off, and the residue is fractionated through a good column. IR (CHCl3) max 1728cm1 . [Fessenden & Fessenden J Org Chem 32 3535 1967, Matsuda et al. J Org Chem 45 237 1980, Beilstein 4 III 1855, 4 IV 3974 for Et ester.]

Properties of Methyl (trimethylsilyl)acetate

Boiling point:	38-39 °C13 mm Hg(lit.)
Density	0.891 g/mL at 25 °C(lit.)
refractive index	n20/D 1.414(lit.)
Flash point:	91 °F
storage temp.	Flammables area
Specific Gravity	0.890
Hydrolytic Sensitivity	2: reacts with aqueous acid
BRN	1098961

Safety information for Methyl (trimethylsilyl)acetate

Signal word	Warning
Pictogram(s)	Flame Flammables GHS02 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H226:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.