METHYL PHOSPHORODICHLORIDITE
Synonym(s):Methyl phosphorodichloridite
- CAS NO.：3279-26-3
- Empirical Formula: CH3Cl2OP
- Molecular Weight: 132.91
- MDL number: MFCD00000524
- EINECS: 221-915-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:25:51
What is METHYL PHOSPHORODICHLORIDITE?
Chemical properties
Colourless Liquid
The Uses of METHYL PHOSPHORODICHLORIDITE
Employed in the synthesis of phosphorodichloridothioates1 and oxazaphosphorinanes2 from sulfenyl chlorides and a chiral amino alcohol, respectively.
The Uses of METHYL PHOSPHORODICHLORIDITE
Methyl dichlorophosphite has been employed in the preparation of:
- phosphonamidate- and phosphonate-linked phosphonopeptides
- 2-(2-iodophenyl)ethyl methyl phosphite derivative of an alcohol
- deoxyoligonucleotides on a polymer support
- cis- and trans-2-oxo-2-propionyl-1,3,2-oxazaphosphorinane
- phosphorodichloridothioates
- oxazaphosphorinanes
Properties of METHYL PHOSPHORODICHLORIDITE
| Melting point: | -91 °C (lit.) |
| Boiling point: | 93-95 °C (lit.) |
| Density | 1.376 g/mL at 20 °C (lit.) |
| refractive index | n |
| Flash point: | 104 °F |
| storage temp. | −20°C |
| solubility | soluble in Chloroform, Dichloromethane, Ethyl Acetate |
| form | liquid |
| color | Colorless to Almost colorless |
| Water Solubility | Reacts with water. Soluble in chloroform, dichloromethane and ethyl acetate. |
| Sensitive | Moisture Sensitive |
| BRN | 1697452 |
| Stability: | Flammable. |
| CAS DataBase Reference | 3279-26-3(CAS DataBase Reference) |
Safety information for METHYL PHOSPHORODICHLORIDITE
| Signal word | Danger |
| Pictogram(s) |
 Flame Flammables GHS02  Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H226:Flammable liquids H314:Skin corrosion/irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for METHYL PHOSPHORODICHLORIDITE
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