METHYL-D3-MALONIC ACID

Synonym(s):2-(Methyl-d₃)propanedioic acid

CAS NO.：42522-59-8
Empirical Formula: C4H3D3O4
Molecular Weight: 121.11
MDL number: MFCD00144783
EINECS: 686-010-1
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-21 10:31:43

What is METHYL-D3-MALONIC ACID?

Chemical properties

White to Off-White Solid

The Uses of METHYL-D3-MALONIC ACID

Methyl-d3-malonic acid is an isotope labelled derivative of Methylmalonic Acid (M318860), binds with coenzyme A to form methylmalonyl-CoA, also a metabolic intermediate transformed to succinic acid (SA) by a vitamin B12-depend ent catalytic step, and is broadly used as a clinical biomarker of functional vitamin B12 status.

The Uses of METHYL-D3-MALONIC ACID

An isotope labelled derivative of Methylmalonic Acid (M318860), binds with coenzyme A to form methylmalonyl-CoA, also a metabolic intermediate transformed to succinic acid (SA) by a vitamin B12-dependent catalytic step, and is broadly used as a clinical biomarker of functional vitamin B12 status.

General Description

Methylmalonic acid, a malonic acid derivative, is a vital intermediate in the metabolism of fat and proteins and plays a key role in energy metabolism. Elevated methylmalonic acid levels can be caused by an inborn error of metabolism leading to methylmalonic aciduria or indicate early vitamin B<sub>12</sub> deficiency. This internal standard is suitable for quantitation of methylmalonic acid levels by LC/MS or GC/MS in newborn screening and clinical testing applications to test for methylmalonic acidemia and diagnose vitamin B<sub>12</sub> deficiency.

Properties of METHYL-D3-MALONIC ACID

Melting point:	134-136 °C(lit.)
Flash point:	2 °C
storage temp.	-20°C
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
color	White to Off-White

Safety information for METHYL-D3-MALONIC ACID

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.