METHYL-D3-MALONIC ACID
Synonym(s):2-(Methyl-d3)propanedioic acid
- CAS NO.：42522-59-8
- Empirical Formula: C4H3D3O4
- Molecular Weight: 121.11
- MDL number: MFCD00144783
- EINECS: 686-010-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 02:54:41
What is METHYL-D3-MALONIC ACID?
Chemical properties
White to Off-White Solid
The Uses of METHYL-D3-MALONIC ACID
Methyl-d3-malonic acid is an isotope labelled derivative of Methylmalonic Acid (M318860), binds with coenzyme A to form methylmalonyl-CoA, also a metabolic intermediate transformed to succinic acid (SA) by a vitamin B12-depend ent catalytic step, and is broadly used as a clinical biomarker of functional vitamin B12 status.
The Uses of METHYL-D3-MALONIC ACID
An isotope labelled derivative of Methylmalonic Acid (M318860), binds with coenzyme A to form methylmalonyl-CoA, also a metabolic intermediate transformed to succinic acid (SA) by a vitamin B12-dependent catalytic step, and is broadly used as a clinical biomarker of functional vitamin B12 status.
General Description
Methylmalonic acid, a malonic acid derivative, is a vital intermediate in the metabolism of fat and proteins and plays a key role in energy metabolism. Elevated methylmalonic acid levels can be caused by an inborn error of metabolism leading to methylmalonic aciduria or indicate early vitamin B<sub>12</sub> deficiency. This internal standard is suitable for quantitation of methylmalonic acid levels by LC/MS or GC/MS in newborn screening and clinical testing applications to test for methylmalonic acidemia and diagnose vitamin B<sub>12</sub> deficiency.
Properties of METHYL-D3-MALONIC ACID
| Melting point: | 134-136 °C(lit.) |
| Flash point: | 2 °C |
| storage temp. | -20°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| color | White to Off-White |
Safety information for METHYL-D3-MALONIC ACID
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for METHYL-D3-MALONIC ACID
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