Methyl 2-methoxy-5-sulfamoylbenzoate

CAS NO.：33045-52-2
Empirical Formula: C9H11NO5S
Molecular Weight: 245.25
MDL number: MFCD01317542
EINECS: 251-358-1
SAFETY DATA SHEET (SDS)
Update Date: 2026-01-13 11:27:04

What is Methyl 2-methoxy-5-sulfamoylbenzoate?

The Uses of Methyl 2-methoxy-5-sulfamoylbenzoate

Methyl 2-methoxy-5-sulfamoylbenzoate is a reactant used in the preparation of many pharmaceutical compounds used as anticoagulants, HCV NS5B polymerase inhibitors, therapeutic drugs for treatment of neurodegenerative diseases and oral hypog lycemic agents.

What are the applications of Application

Methyl 2-methoxy-5-sulfamoylbenzoate is a sulfur containing compound

Preparation

Methyl 2-methoxy-5-aminosulfonyl benzoate is an important intermediate for the synthesis of sulpiride, which is the main drug for treatment of psychiatric disorders such as schizophrenia and depression. The synthetic route of methyl 2-methoxy-5-aminosulfonyl benzoate is composed mainly of etherification (phenol hydroxyl), sulfonyl chloride, amination and esterification, which prepared successfully with the help of salicylic acid and methyl salicylate as precursor. The raw materials of the synthetic route are salicylic acid and methyl salicylate, which was synthesized by etherification (phenol hydroxyl), sulfonyl chloride, amination and esterification.
synthesis of Methyl 2-Methoxy-5-Aminosulfonyl Benzoate
synthetic procedure of Methyl 2-Methoxy-5-Aminosulfonyl Benzoate

General Description

Methyl 2-methoxy-5-sulfamoylbenzoate is also referred to as 2-methoxy-5-sulfamoyl methyl benzoate or methyl 5-(aminosulphonyl)-2-methoxybenzoate.

Properties of Methyl 2-methoxy-5-sulfamoylbenzoate

Melting point:	175-177 °C (lit.)
Boiling point:	439.8±55.0 °C(Predicted)
Density	1.360±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
form	neat
pka	9.94±0.60(Predicted)
color	White to Off-White
CAS DataBase Reference	33045-52-2(CAS DataBase Reference)

Safety information for Methyl 2-methoxy-5-sulfamoylbenzoate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection.