Methyl 1-bromocyclohexanecarboxylate
- CAS NO.：3196-23-4
- Empirical Formula: C8H13BrO2
- Molecular Weight: 221.09
- MDL number: MFCD00134214
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-09-12 18:49:14
What is Methyl 1-bromocyclohexanecarboxylate?
The Uses of Methyl 1-bromocyclohexanecarboxylate
Methyl 1-bromocyclohexanecarboxylate may be used in the improved method of preparation of methyl 3-oxo-1-cyclohexene-1-carboxylate. It may be used in the Reformatsky synthesis of 16-aryl-15-oxadispiro[5.1.5.3]hexadecane-7,14-diones.
General Description
Methyl 1-bromocyclohexanecarboxylate reacts with zinc and substituted chalcones to yield the corresponding spiro-3,4-dihydropyran-2-one derivatives, 3-aryl-5-aryl-2-oxaspiro[5.5]undec-3-en-1-ones. Reformatsky reaction of methyl 1-bromocyclohexanecarboxylate with 2-aryl-2-oxoacetaldehyde is reported. Methyl 1-bromocyclohexanecarboxylate reacts with zinc and amides or methylamides of 3-aryl-2-cyanopropenoic acids to yield 5-aryl-1,3-dioxo-2-azaspiro[5.5]undecane-4-carbonitriles or 5-aryl-2-methyl-1,3-dioxo-2-azaspiro[5.5]undecane-4-carbonitriles.
Properties of Methyl 1-bromocyclohexanecarboxylate
| Boiling point: | 115-116 °C/19 mmHg (lit.) |
| Density | 1.39 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | 222 °F |
| storage temp. | 2-8°C |
Safety information for Methyl 1-bromocyclohexanecarboxylate
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Methyl 1-bromocyclohexanecarboxylate
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