2-Bromo-2-methylpropionic acid
Synonym(s):α-Bromoisobutyric acid;2-Bromo-2-methylpropionic acid
- CAS NO.：2052-01-9
- Empirical Formula: C4H7BrO2
- Molecular Weight: 167
- MDL number: MFCD00004168
- EINECS: 218-139-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-09-25 17:15:13
What is 2-Bromo-2-methylpropionic acid?
Chemical properties
white powder
The Uses of 2-Bromo-2-methylpropionic acid
2-Bromoisobutyric acid is used in the synthesis of dextran macroinitiator for atom transfer radical polymerization (ATRP) by partial esterification of hydroxyl group of the polysaccharide. The multifunctional silica colloids were prepared by coating them with 2-bromo-2-methylpropionic acid stabilized quantum dots.
The Uses of 2-Bromo-2-methylpropionic acid
2-Bromo-2-methylpropionic acid is used in the Herceptin functionalization of polyhedral oligomeric silsesquioxane-conjugated oligomers-silica /iron oxide nanoparticles for tumor cell sorting.
General Description
The multifunctional silica colloids were prepared by coating them with 2-bromo-2-methylpropionic acid stabilized quantum dots.
Properties of 2-Bromo-2-methylpropionic acid
| Melting point: | 44-47 °C(lit.) |
| Boiling point: | 198-200 °C(lit.) |
| Density | 1.43 g/cm3 |
| refractive index | 1.4570 (estimate) |
| Flash point: | >230 °F |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | soluble in Chloroform, Methanol |
| pka | 2.91±0.10(Predicted) |
| form | Liquid |
| color | Clear colorless to slightly yellow |
| Water Solubility | Soluble in alcohol and ether. Slightly soluble in water. |
| Merck | 14,1421 |
| BRN | 1745543 |
| Stability: | Stable. Incompatible with strong oxidizing agents, strong bases. |
| CAS DataBase Reference | 2052-01-9(CAS DataBase Reference) |
| NIST Chemistry Reference | «alpha»-Bromoisobutyric acid(2052-01-9) |
| EPA Substance Registry System | Propanoic acid, 2-bromo-2-methyl- (2052-01-9) |
Safety information for 2-Bromo-2-methylpropionic acid
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-Bromo-2-methylpropionic acid
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