methoctramine tetrahydrochloride hemihydrate

The Uses of methoctramine tetrahydrochloride hemihydrate

Methoctramine is a muscarinic M2 receptor antagonist.

The Uses of methoctramine tetrahydrochloride hemihydrate

Methoctramine hydrate has been used:

• As a muscarinic receptor 2 antogonist.
• As a test molecule to check its effect on premature osteogenic differentiation of HGPS (Hutchinson-Gilford progeria syndrome) iPS (induced pluripotent)-derived mesenchymal stem cells.

What are the applications of Application

Methoctramine is a mAChR M2 (muscarinic M2 receptor) antagonist

Definition

ChEBI: A hydrochloride obtained by combining methoctramine with four molar equivalents of hydrochloric acid.

General Description

Methoctramine (N, N′-bis [6-[[(2-methoxyphenyl)-methyl] hexyl]-1, 8-octane] diamine) is a derivative of polymethylene tetramine.

Biochem/physiol Actions

Methoctramine is a selective M2 muscarinic receptor antagonist at nM concentrations. At mM concentrations, methoctramine directly inhibits the high affinity GTPase activity of G proteins. In oesophageal muscle, acetylcholine-mediated increase in calcium and arachidonic acid release were reduced by the M2 receptor antagonist, methoctramine. Methoctramine infused bilaterally in the dorsolateral striatum, considerably enhanced memory in cognitively impaired aged rats. Methoctramine plays a vital role in muscarinic receptor classification.