Methasterone

CAS NO.：3381-88-2
Empirical Formula: C21H34O2
Molecular Weight: 318.5
MDL number: MFCD01670015
EINECS: 1592732-453-0
SAFETY DATA SHEET (SDS)
Update Date: 2025-09-26 17:40:57

What is Methasterone?

The Uses of Methasterone

Methasterone is an anabolic androgenic steroid. Methasterone is one of the anabolic steroids screened by the World Anti-Doping Agency (WADA).

Definition

ChEBI: 17beta-Hydroxy-2alpha,17-dimethyl-5alpha-androstan-3-one is a 3-oxo-5alpha-steroid.

Synthesis

Methasterone is synthesized by Catalytic Oxymetholone in ethanol with the presence palladium on charcoal.
Procedure: 2.05 g Oxymetholone was dissolved in 160 ml ethanol at room temperature. This solution was hydrogenated in a pressure vessel (Parr reactor) with 2.50 g palladium on charcoal (5%) at 3 bar and room temperature for 36 h. The reaction seemed to be completed, since there is no 5 starting material remaining. The formation of two major byproducts can be observed via TLC (Seebach-staining). The mixture was filtered through a short pad of silica and the corresponding ethanol solution was evaporated to yield 1.90 g of a colorless solid. The crude product was purified by column chromatography on silica gel by using hexane-ethyl acetate (1:1), to afford 1.35 g of Methasterone as a colorless solid (68%).

Properties of Methasterone

Melting point:	223-225℃
Boiling point:	423.8±45.0 °C(Predicted)
Density	1.040
solubility	DMF: 3 mg/ml; DMSO: 1 mg/ml; Ethanol: 5 mg/ml; Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/ml
form	A crystalline solid
pka	15.15±0.70(Predicted)
InChI	InChI=1/C21H34O2/c1-13-12-19(2)14(11-18(13)22)5-6-15-16(19)7-9-20(3)17(15)8-10-21(20,4)23/h13-17,23H,5-12H2,1-4H3/t13-,14+,15-,16+,17+,19+,20+,21+/s3

Safety information for Methasterone

Computed Descriptors for Methasterone

InChIKey	QCWCXSMWLJFBNM-DAWJFWDFNA-N
SMILES	C[C@]12C[C@@H](C)C(=O)C[C@]1([H])CC[C@@]1([H])[C@]3([H])CC[C@@](O)(C)[C@@]3(C)CC[C@]21[H] \|&1:1,3,8,12,14,18,21,25,r\|