Methanone, [4-(2'-Methoxy[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl][2-(phenylMethyl)-1-piperidinyl]-

CAS NO.：1402612-56-9
Empirical Formula: C28H28N4O2
Molecular Weight: 452.55
Update Date: 2026-04-24 14:58:37

What is Methanone, [4-(2'-Methoxy[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl][2-(phenylMethyl)-1-piperidinyl]-?

Description

KT172 is a non-selective inhibitor of diacylglycerol lipase α (DAGLα) and DAGLβ. It inhibits DAGL-mediated hydrolysis of 1-stearoyl-2-arachidonoylglycerol in HEK293T cell membranes expressing recombinant DAGLα or DAGLβ (IC₅₀s = 140 and 60 nM, respectively). KT172 also inhibits α/β-hydrolase 6 (ABHD6; IC₅₀ = 5 nM) and weakly inhibits monoacylglycerol lipase (MAGL; IC₅₀ = 5,000 nM) in a panel of 47 mouse serine hydrolases. It restores nicotine-stimulated GABA release in isolated ventral tegmental area (VTA) dopamine neurons from rats chronically exposed to nicotine when used at a concentration of 1 μM. KT172 decreases production of 2-arachidonoyl glycerol and subsequently reduces arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607), prostaglandin E₂ (PGE₂; ), and PGD₂ in thioglycolate-stimulated peritoneal macrophages when administered at a dose of 5 mg/kg in mice.

Properties of Methanone, [4-(2'-Methoxy[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl][2-(phenylMethyl)-1-piperidinyl]-

solubility	DMF:5.0(Max Conc. mg/mL);10.72(Max Conc. mM) DMSO:10.0(Max Conc. mg/mL);21.43(Max Conc. mM) DMSO:PBS (pH 7.2) (1:2):0.25(Max Conc. mg/mL);0.55(Max Conc. mM)
form	A crystalline solid
color	Off-white to light yellow

Safety information for Methanone, [4-(2'-Methoxy[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl][2-(phenylMethyl)-1-piperidinyl]-

Computed Descriptors for Methanone, [4-(2'-Methoxy[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl][2-(phenylMethyl)-1-piperidinyl]-

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