Methanone, [2-amino-4-[3-(trifluoromethyl)phenyl]-3-thienyl]phenyl-

CAS NO.：1018830-99-3
Empirical Formula: C18H12F3NOS
Molecular Weight: 347.35
MDL number: MFCD34601853
Update Date: 2026-08-30 11:39:11

What is Methanone, [2-amino-4-[3-(trifluoromethyl)phenyl]-3-thienyl]phenyl-?

Biological Activity

VCP171 is a positive allosteric modulator of adenosine A1 receptors (EC50 = 15.8 μM in a kinetic assay measuring agonist dissociation).1. It reduces AMPA receptor-mediated evoked excitatory postsynaptic currents (eEPSCs) in lamina I and lamina II neurons in a rat model of neuropathic pain (EC50s = 1.995 and 0.251 μM, respectively) to a greater extent than in sham control animals (EC50s = 2.512 and 0.631 μM, respectively).2

Storage

Store at -20°C

References

1.Aurelio, L., Figler, H., Flynn, B.L., et al.5-Substituted 2-aminothiophenes as A1 adenosine receptor allosteric enhancersBioorg. Med. Chem.16(3)1319-1327(2008) 2.Imlach, W.L., Bhola, R.F., May, L.T., et al.A positive allosteric modulator of the adenosine A1 receptor selectively inhibits primary afferent synaptic transmission in a neuropathic pain modelMol. Pharm.88(3)460-468(2015)

Properties of Methanone, [2-amino-4-[3-(trifluoromethyl)phenyl]-3-thienyl]phenyl-

Boiling point:	507.0±50.0 °C(Predicted)
Density	1.345±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml,Ethanol: 10 mg/ml
form	A crystalline solid
pka	-1.73±0.14(Predicted)

Safety information for Methanone, [2-amino-4-[3-(trifluoromethyl)phenyl]-3-thienyl]phenyl-

Computed Descriptors for Methanone, [2-amino-4-[3-(trifluoromethyl)phenyl]-3-thienyl]phenyl-

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