Methanone, 1-naphthalenyl[1-[3-(2-oxiranyl)propyl]-1H-indol-3-yl]-

CAS NO.：2365471-31-2
Empirical Formula: C24H21NO2
Molecular Weight: 355.43
Update Date: 2026-05-28 03:02:28

What is Methanone, 1-naphthalenyl[1-[3-(2-oxiranyl)propyl]-1H-indol-3-yl]-?

Description

JWH 018 is a synthetic cannabinoid (CB) that potently activates the central CB₁ and peripheral CB₂ receptors (K_i = 9.0 and 2.94 nM, respectively).¹ This cannabimimetic compound has frequently been found in herbal blends. ^2,3,4 JWH 018 N-(4,5-epoxypentyl) analog is distinguished by a terminal epoxide group on the alkyl chain. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic and research purposes.

References

1. Aung, M.M., Griffin, G., Huffman, J.W., et al. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB₁ and CB₂ receptor binding Drug Alcohol Depend. 60(2),133-140(2000).
2. Auw?rter, V., Dresen, S., Weinmann, W., et al. “Spice” and other herbal blends: Harmless incense or cannabinoid designer drugs? J. Mass Spectrom. 44(5),832-837(2009).
3. Lindigkeit, R., Boehme, A., Eiserloh, I., et al. Spice: A never ending story? Forensic Sci. Int. 191(1-3),58-63(2009).
4. Uchiyama, N., Kikura-Hanajiri, R., Kawahara, N., et al. Identification of a cannabimimetic indole as a designer drug in a herbal product Forensic Toxicol. 27,61-66(2009).

Properties of Methanone, 1-naphthalenyl[1-[3-(2-oxiranyl)propyl]-1H-indol-3-yl]-

Boiling point:	573.3±20.0 °C(Predicted)
Density	1.22±0.1 g/cm3(Predicted)
solubility	DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml; Methanol: 30 mg/ml

Safety information for Methanone, 1-naphthalenyl[1-[3-(2-oxiranyl)propyl]-1H-indol-3-yl]-

Computed Descriptors for Methanone, 1-naphthalenyl[1-[3-(2-oxiranyl)propyl]-1H-indol-3-yl]-

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