Methacetin
- CAS NO.：51-66-1
- Empirical Formula: C9H11NO2
- Molecular Weight: 165.19
- MDL number: MFCD00014963
- EINECS: 200-114-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 14:15:30
What is Methacetin?
Chemical properties
LIGHT BEIGE CRYSTALLINE POWDER
The Uses of Methacetin
Methacetin is evaluated in a breath test to predict early liver disfunction due to valproic acid and other cause. Methacetin breath test (MBT) is a rapid, non-invasive assessment of liver function in acute severe liver disease and a potential key tool in future dignosis.
Definition
ChEBI: Methacetin is a member of the class of acetamides that is paracetamol in which the hydrogen of phenolic hydroxy group has been replaced by a methyl group. It is a member of acetamides and an aromatic ether. It is functionally related to a p-anisidine and a paracetamol.
Synthesis Reference(s)
Journal of the American Chemical Society, 89, p. 7131, 1967 DOI: 10.1021/ja01002a061
The Journal of Organic Chemistry, 42, p. 3755, 1977
Organic Syntheses, Coll. Vol. 3, p. 661, 1955
Safety Profile
Moderately toxic by ingestion andother unspecified routes. When heated to decomposition itemits toxic fumes of NOx.
Properties of Methacetin
| Melting point: | 128-130 °C(lit.) |
| Boiling point: | 293.03°C (rough estimate) |
| Density | 1.1603 (rough estimate) |
| refractive index | 1.5839 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 14.53±0.70(Predicted) |
| form | Crystalline |
| color | White |
| Water Solubility | 0.42 g/100 mL (20 ºC) |
| Merck | 14,51 |
| BRN | 387887 |
| Stability: | Hygroscopic |
| CAS DataBase Reference | 51-66-1(CAS DataBase Reference) |
| NIST Chemistry Reference | N-(4-Methoxyphenyl)acetic acid amide(51-66-1) |
| EPA Substance Registry System | Acetamide, N-(4-methoxyphenyl)- (51-66-1) |
Safety information for Methacetin
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P501:Dispose of contents/container to..… |
Computed Descriptors for Methacetin
Methacetin manufacturer
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