mefruside
- CAS NO.：7195-27-9
- Empirical Formula: C13H19ClN2O5S2
- Molecular Weight: 382.88
- MDL number: MFCD00867319
- EINECS: 2305624
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-07-27 17:00:41
What is mefruside?
Originator
Baycaron,Bayer,W. Germany,1967
The Uses of mefruside
Mefruside is a diuretic used for the treatment of edema and hypertension.
Definition
ChEBI: Mefruside is an organic molecular entity.
Manufacturing Process
By hydrogenation of α-methyl-α-cyanotetrahydrofuran with Raney nickel as catalyst, α-methyl-α-tetrahydrofurfuryl amine is obtained (BP 48°C/12 mm Hg) which is alkylated by dimethyl sulfate to give α-methyl-αtetrahydrofurfurylmethylamine (BP 70°C/40 mm Hg). The amine is then reacted with 4-chloro-3-sulfamyl benzene sulfochloride in the presence of an acid acceptor. The mixture is stirred overnight, the solvent (acetone or pyridine) is driven off under vacuum and the residue is recrystallized from alcohol.
Therapeutic Function
Diuretic
Properties of mefruside
| Melting point: | 149.5°C |
| Boiling point: | 565.2±60.0 °C(Predicted) |
| Density | 1.3150 (rough estimate) |
| refractive index | 1.6100 (estimate) |
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| pka | 9.26±0.60(Predicted) |
| form | Solid |
| color | White to Pale Beige |
| Stability: | Hygroscopic |
Safety information for mefruside
Computed Descriptors for mefruside
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