Mal-PEG4-Val-Cit-PAB-PNP
- CAS NO.：2112738-09-5
- Empirical Formula: C40H53N7O15
- Molecular Weight: 871.89
- MDL number: MFCD30828694
- Update Date: 2025-07-16 09:55:30
What is Mal-PEG4-Val-Cit-PAB-PNP?
Description
Mal-PEG4-Val-Cit-PAB-PNP is a cleavable ADC linker. The Val-Cit linkers can be cleaved by Cathepsin B. Maleimide (Mal) group is reactive toward thiol groups. PEG space improve compound's aqueous solubility. PNP is a good leaving group.
Biological Activity
Mal-PEG4-Val-Cit-PAB-PNP is a cleavable ADC linker containing 4 units of PEG, which can be used to synthesize antibody drug conjugates (ADC).
in vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
Properties of Mal-PEG4-Val-Cit-PAB-PNP
| solubility | Soluble in DMSO, DMF |
| form | Solid |
| color | Light yellow to yellow |
Safety information for Mal-PEG4-Val-Cit-PAB-PNP
Computed Descriptors for Mal-PEG4-Val-Cit-PAB-PNP
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