Mal-PEG4-Glu(TFP ester)-NH-m-PEG24
- CAS NO.：2408741-87-5
- Empirical Formula: C78H134F4N4O35
- Molecular Weight: 1763.9
- MDL number: MFCD31657174
- Update Date: 2025-04-17 18:22:24
What is Mal-PEG4-Glu(TFP ester)-NH-m-PEG24?
Biological Activity
Mal-PEG4-Glu(TFP ester)-NH-m-PEG24 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Properties of Mal-PEG4-Glu(TFP ester)-NH-m-PEG24
| Boiling point: | 1305.2±65.0 °C(Predicted) |
| Density | 1.198±0.06 g/cm3(Predicted) |
| pka | 13.98±0.46(Predicted) |
Safety information for Mal-PEG4-Glu(TFP ester)-NH-m-PEG24
Computed Descriptors for Mal-PEG4-Glu(TFP ester)-NH-m-PEG24
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