MAC-545496
- CAS NO.：838810-96-1
- Empirical Formula: C18H18ClN5O3S
- Molecular Weight: 419.89
- Update Date: 2026-05-27 22:53:53
What is MAC-545496?
Description
MAC-545496 (838810-96-1) is an inhibitor of glycopeptide-resistance-associated protein R (GraR, also known as ApsR).? GraR and its regulatory system are important for virulence of S. aureus.? MAC-545496 is able to reverse ?-lactam resistance in S. aureus in a G. Mellonella larvae model.? 0.06 μg/mL MAC-545496? lowered the minimum inhibitory concentration (MIC) for oxacillin against S. aureus below the CLSI clinical breakpoint. It lowered the ?-lactam MIC from 512 to 8 μg/mL against S. aureus USA300.
References
El-Halfawy et al. (2020), Discovery of an antivirulence compound that reverses ?-lactam resistance in MRSA; Nat. Chem. Biol., 16 143
Properties of MAC-545496
| Density | 1.458±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO (25 mg/ml) |
| form | solid |
| pka | 7.09±0.70(Predicted) |
| color | Yellow/orange |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month |
Safety information for MAC-545496
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for MAC-545496
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