m-PEG11-acid
- CAS NO.：2280998-74-3
- Empirical Formula: C24H48O13
- Molecular Weight: 544.64
- MDL number: MFCD27977512
- Update Date: 2026-07-16 07:06:08
What is m-PEG11-acid?
Description
m-PEG11-acid is a PEG linker containing a terminal carboxylic acid. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media.
Biological Activity
M-PEG11-acid is a non-cleavable ADC linker containing 11-unit PEG, which can be used to synthesize antibody drug conjugates (ADC). m-PEG11-acid is also a PROTAC linker, belonging to the PEG class, which can be used to synthesize PROTAC molecules.
in vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Properties of m-PEG11-acid
| Boiling point: | 599.1±50.0 °C(Predicted) |
| Density | 1.113±0.06 g/cm3(Predicted) |
| solubility | DMSO : 100 mg/mL (183.61 mM; Need ultrasonic) |
| form | Liquid |
| pka | 4.28±0.10(Predicted) |
| color | Colorless to light yellow |
Safety information for m-PEG11-acid
Computed Descriptors for m-PEG11-acid
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