lymecycline
- CAS NO.:992-21-2
- Empirical Formula: C29H38N4O10
- Molecular Weight: 602.63
- MDL number: MFCD01716199
- EINECS: 213-592-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-27 11:17:45
What is lymecycline?
Absorption
Lymecycline is 77-88% absorbed after oral administration with a relative bioavailability of 70%. The Cmax of lymecycline is 2.1 mg/L and is achieved about 3 hours after administration. The AUC is 21.9 ± 4.3 mg·h/L.
Toxicity
The oral LD50 of lymecycline in rats is 3200 mg/kg. Overdoses with lymecycline are rare. In the case of an overdose, gastric lavage should be performed immediately. Provide supportive treatment and maintain fluid balance.
The Uses of lymecycline
Labelled Lymecycline. A semi-synthetic antibiotic related to Tetracycline (T291400). Antibacterial.
Indications
Lymecycline is used for the treatment of acne in addition to other susceptible infections; propionibacterium is often the cause of acne. Some of the infections that can be treated with lymecycline include upper respiratory tract infections, urinary tract infections, bronchitis, chlamydial infections, and rickettsial infections.
Background
Lymecycline is a broad-spectrum second-generation tetracycline antibiotic used for the treatment of acne and other susceptible bacterial infections. It has been proven a cost-effective alternative to treatment with minocycline with comparable safety and efficacy. Lymecycline was initially discovered in 1961. It is marketed by Galderma and used in the UK as well as New Zealand in addition to other countries. Lymecycline is not marketed in the USA, however, equivalent drugs are available, such as minocycline and tetracycline.
What are the applications of Application
Lymecycline is a semi-synthetic antibiotic related to Tetracycline (sc-205858)
Pharmacokinetics
Lymecycline, like other tetracyclines, exerts bacteriostatic actions on intracellular and extracellular bacteria, treating susceptible bacterial infections. It has been shown to be safe and effective in the treatment of moderate to severe acne.
It is important to note that like other tetracyclines, lymecycline may cause esophageal irritation and ulceration, which can be prevented by drinking adequate fluids during administration. It also has the potential to cause photosensitivity. Lymecycline can lead to renal tubular acidosis or hepatic toxicity. It is not recommended to administer this drug in patients with renal disease or severe hepatic disease.
Metabolism
Not Available
Properties of lymecycline
Melting point: | 192.5°C |
Boiling point: | 648.97°C (rough estimate) |
Density | 1.53 |
storage temp. | Amber Vial, -86°C Freezer, Under inert atmosphere |
solubility | Very soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride. |
form | Solid |
color | Yellow to Dark Brown |
Safety information for lymecycline
Computed Descriptors for lymecycline
Abamectin manufacturer
Vadivarhe Speciality Chemicals Limited
REXIN Laboratories (Redson Group)
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