Ly93

CAS NO.：1883528-69-5
Empirical Formula: C21H20N2O2
Molecular Weight: 332.4
MDL number: MFCD32067900
Update Date: 2026-04-24 14:58:28

What is Ly93?

Biological Activity

Ly93 is a selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, with an IC50 of 91 nM[1]. Ly93 (100 mg/kg, i.g. once daily for 7 days) significantly decreases the plasma SM levels of C57BL/6J mice[1].Ly93 dose-dependently attenuates the atherosclerotic lesions in the root and the entire aorta as well as macrophage content in lesions, in apolipoprotein E gene knockout mice[1].

References

[1]. Li Y, et al. Discovery, synthesis and anti-atherosclerotic activities of a novel selective sphingomyelin synthase 2 inhibitor. Eur J Med Chem. 2019 Feb 1;163:864-882.

Properties of Ly93

Boiling point:	450.6±35.0 °C(Predicted)
Density	1.191±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 250 mg/mL (752.11 mM; Need ultrasonic)
pka	12.67±0.70(Predicted)
form	Solid
color	Off-white to light yellow

Safety information for Ly93

Computed Descriptors for Ly93

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