LY 344864
Synonym(s):N-[(3R)-3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluoro-benzamide hydrochloride
- CAS NO.：186544-26-3
- Empirical Formula: C21H22FN3O
- Molecular Weight: 351.42
- MDL number: MFCD07772184
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-11-05 08:34:14
What is LY 344864?
The Uses of LY 344864
LY-344864 Hydrochloride is used as a selective 5-HTIF receptor agonist.
What are the applications of Application
LY 344864 hydrochloride is a potent and selective SR-1F agonist
Biological Activity
Potent, selective 5-HT 1F receptor agonist (EC 50 = 3 nM). Displays > 80-fold selectivity over other 5-HT receptors (K i values are 0.006, 0.53, 0.55, 0.56, 1.42, 1.70, 3.50, 3.94 and 4.85 μ M for 5-HT 1F , 5-HT 1A , 5-HT 1B , 5-HT 1D , 5-HT 1E , 5-HT 2B , 5-HT 2C , 5-HT 2A and 5-HT 7 receptors respectively). Inhibits neurogenic dural inflammation in vivo following i.v. and oral administration.
Properties of LY 344864
| Boiling point: | 471.9±45.0 °C(Predicted) |
| Density | 1.28±0.1 g/cm3(Predicted) |
| storage temp. | Store at +4°C |
| solubility | DMSO : ≥ 350 mg/mL (995.96 mM) |
| form | Powder |
| pka | 14.12±0.40(Predicted) |
| color | White to off-white |
Safety information for LY 344864
Computed Descriptors for LY 344864
New Products
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