LY 223982

CAS NO.：117423-74-2
Empirical Formula: C30H30O7
Molecular Weight: 502.55
MDL number: MFCD00876442
SAFETY DATA SHEET (SDS)
Update Date: 2026-03-02 19:25:49

What is LY 223982?

Description

Leukotriene B₄ (LTB₄) is a dihydroxy fatty acid derived from the 5-lipoxygenase pathway of arachidonic acid metabolism and is an important mediator of the inflammatory process. The benzophenone dicarboxylic acid derivative LY223982 is a potent BLT₁ receptor antagonist. It inhibits the specific binding of radiolabeled-LTB₄ to isolated human neutrophils with an IC₅₀ value of 13.2 nM. LY223982 inhibits the leukotriene B₄ (LTB₄)-induced aggregation of guinea pig and human neutrophils with IC₅₀ values of 74 and 100 nM, respectively. However, concentrations of LY223982 up to 10 μM do not inhibit binding of LTB₄ to human BLT₁ or BLT₂ expressed in CHO cells.

The Uses of LY 223982

LY223982 is a potent P2Y7 (BLT1) receptor antagonist.

What are the applications of Application

LY223982 is a potent P2Y7 (BLT1) receptor antagonist

Properties of LY 223982

Melting point:	151-152 °C
Boiling point:	753.8±60.0 °C(Predicted)
Density	1.235±0.06 g/cm3(Predicted)
storage temp.	-20°C Freezer
solubility	Chloroform (Slightly, Heated, Sonicated), DMSO (Very Slightly)
pka	3.81±0.10(Predicted)
form	A crystalline solid
color	White to off-white