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Home Product name listLY 223982

LY 223982

CAS NO.：117423-74-2
Empirical Formula: C30H30O7
Molecular Weight: 502.56
MDL number: MFCD00876442
SAFETY DATA SHEET (SDS)
Update Date: 2026-07-14 16:49:18

LY 223982 Structural

What is LY 223982?

Description

Leukotriene B₄ (LTB₄) is a dihydroxy fatty acid derived from the 5-lipoxygenase pathway of arachidonic acid metabolism and is an important mediator of the inflammatory process. The benzophenone dicarboxylic acid derivative LY223982 is a potent BLT₁ receptor antagonist. It inhibits the specific binding of radiolabeled-LTB₄ to isolated human neutrophils with an IC₅₀ value of 13.2 nM. LY223982 inhibits the leukotriene B₄ (LTB₄)-induced aggregation of guinea pig and human neutrophils with IC₅₀ values of 74 and 100 nM, respectively. However, concentrations of LY223982 up to 10 μM do not inhibit binding of LTB₄ to human BLT₁ or BLT₂ expressed in CHO cells.

The Uses of LY 223982

LY223982 is a potent P2Y7 (BLT1) receptor antagonist.

What are the applications of Application

LY223982 is a potent P2Y7 (BLT1) receptor antagonist

Properties of LY 223982

Melting point:	151-152 °C
Boiling point:	753.8±60.0 °C(Predicted)
Density	1.235±0.06 g/cm3(Predicted)
storage temp.	-20°C Freezer
solubility	Chloroform (Slightly, Heated, Sonicated), DMSO (Very Slightly)
pka	3.81±0.10(Predicted)
form	A crystalline solid
color	White to off-white

Safety information for LY 223982

Computed Descriptors for LY 223982

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5-bromo-4-fluoro-2-nitrobenzaldehyde (R)-(-)-2-Amino-1-propanol Cyclobutanone Fmoc-OSu 1-(2-Chloroethyl)pyrrolidine Hydrochloride 2-Amino-2-(4-methylphenyl)acetic acid β-Bromostyrene Ethyl 3-phenylpropanoate Phenethyl cinnamate Dipropyl disulfide 4 pentyn 1 ol N-Vinylformamide Methacrylate-PEG-Methacrylate, Mn:35000 2,4-Dihydroxyacetophenone 2-Chloro 5-Fluoro Pyridine Vasicinone 2-Chloroisonicotinic Acid Tween 80 or Polysorbate 80 2-Butyn-1-oL 2-Pentyn-1-oL 4-Nitrobenzotrifluoride N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine Pirtobrutinib intd. N-(4-Cyano-3-(trifluoromethyl)phenyl)-2-methyloxirane-2-carboxamide

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LY 223982

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