LINDERANE
- CAS NO.：13476-25-0
- Empirical Formula: C15H16O4
- Molecular Weight: 260.29
- MDL number: MFCD07781424
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-17 13:05:51
What is LINDERANE?
Description
Linderane is a sesquiterpene that has been found in L. aggregata. It inhibits the cytochrome P450 (CYP) isoform CYP2C9 (Ki = 1.26 μM) in an irreversible and NADPH-dependent manner. Linderane decreases phosphoenolpyruvate carboxykinase (Pck1) and glucose-6-phosphatase (G6pc) gene expression, cAMP concentration, and CREB phosphorylation, increases phosphodiesterase 3 (PDE3) activity, and inhibits gluconeogenesis in rat primary hepatocytes. In vivo, linderane (50 mg/kg twice per day) decreases serum and hepatic triglyceride levels, as well as random-fed and fasting blood glucose levels in ob/ob mice.
The Uses of LINDERANE
Linderane is a sequiterpene lactone extract from Lindera strychnifolia compound used as a cytotoxic agent against hepaic stellate cells.
Definition
ChEBI: Linderane is a member of dioxanes.
Properties of LINDERANE
| Melting point: | 190～191℃ |
| Boiling point: | 434.5±45.0 °C(Predicted) |
| Density | 1.30±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| color | White to Off-White |
| Stability: | Hygroscopic |
Safety information for LINDERANE
Computed Descriptors for LINDERANE
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