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HomeProduct name listLINDERANE

LINDERANE

LINDERANE Structural

What is LINDERANE?

Description

Linderane is a sesquiterpene that has been found in L. aggregata. It inhibits the cytochrome P450 (CYP) isoform CYP2C9 (Ki = 1.26 μM) in an irreversible and NADPH-dependent manner. Linderane decreases phosphoenolpyruvate carboxykinase (Pck1) and glucose-6-phosphatase (G6pc) gene expression, cAMP concentration, and CREB phosphorylation, increases phosphodiesterase 3 (PDE3) activity, and inhibits gluconeogenesis in rat primary hepatocytes. In vivo, linderane (50 mg/kg twice per day) decreases serum and hepatic triglyceride levels, as well as random-fed and fasting blood glucose levels in ob/ob mice.

The Uses of LINDERANE

Linderane is a sequiterpene lactone extract from Lindera strychnifolia compound used as a cytotoxic agent against hepaic stellate cells.

Definition

ChEBI: Linderane is a member of dioxanes.

Properties of LINDERANE

Melting point: 190～191℃
Boiling point: 434.5±45.0 °C(Predicted)
Density  1.30±0.1 g/cm3(Predicted)
storage temp.  -20°C
solubility  Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form  Solid
color  White to Off-White
Stability: Hygroscopic

Safety information for LINDERANE

Computed Descriptors for LINDERANE

New Products

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