LH1306

CAS NO.：2182653-84-3
Empirical Formula: C38H48N6O6
Molecular Weight: 684.82
Update Date: 2026-05-11 19:39:08

What is LH1306?

Description

LH1306 is an inhibitor of the interaction between programmed cell death 1 (PD-1) and its ligand PD-L1. It increases the activation of Jurkat cells expressing PD-1 in co-culture with U2OS or CHO cells expressing PD-L1.

in vitro

C2-symmetric inhibitors 2a (LH1306) and 2b (LH1307) exhibited IC50 values of 25 and 3.0 nM, respectively, in the HTRF assay. In one cell-based coculture PD-1 signaling assay, 2a and 2b were 8.2- and 2.8-fold more potent in inhibiting PD-1 signaling than 1a and 1b, respectively._x000D_ _x000D_ Reference: J Med Chem. 2019 Aug 8;62(15):7250-7263. https://pubmed.ncbi.nlm.nih.gov/31298541/

Properties of LH1306

Boiling point:	854.4±65.0 °C(Predicted)
Density	1.170±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF:1.0(Max Conc. mg/mL);1.46(Max Conc. mM) DMSO:0.25(Max Conc. mg/mL);0.37(Max Conc. mM)
form	A crystalline solid
pka	15.76±0.46(Predicted)

Safety information for LH1306

Computed Descriptors for LH1306

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