LFM-A13

Synonym(s):α-Cyano-β-hydroxy-β-methyl-N-(2,5-dibromophenyl)propenamide;α-Cyano-β-hydroxy-β-methyl-N-(2,5-dibromophenyl)propenamide, BTK Inhibitor I, Bruton′s Tyrosine Kinase Inhibitor I;(2Z)-2-Cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-butenamide; a-Cyano-b-hydroxy-b-methyl-N-(2,5-dibromophenyl)propenamide;LFM-A13 - CAS 62004-35-7 - Calbiochem

CAS NO.：62004-35-7
Empirical Formula: C11H8Br2N2O2
Molecular Weight: 360
MDL number: MFCD02179204
SAFETY DATA SHEET (SDS)
Update Date: 2026-01-13 11:20:46

What is LFM-A13?

The Uses of LFM-A13

LFM-A13 is a novel anti-leukemic agent targeting Bruton''s tyrosine kinase (BTK). LFM-A13 is a BTK inhibitor.

What are the applications of Application

LFM-A13 is a potent and selective inhibitor of Btk

Biological Activity

Potent and selective inhibitor of Bruton's tyrosine kinase (BTK). Inhibits recombinant BTK with an IC 50 value of 2.5 μ M and has no activity on other protein kinases ( including JAK1, JAK3, HCK, EGFR kinase and insulin receptor kinase) at concentrations of up to 278 μ M.

Storage

Store at RT

Properties of LFM-A13

storage temp.	−20°C
solubility	DMSO: 15 mg/mL
form	powder
color	white

Safety information for LFM-A13

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P501:Dispose of contents/container to..…

Computed Descriptors for LFM-A13

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