LAS191859

CAS NO.：1420071-13-1
Empirical Formula: C24H24F3N3O3
Molecular Weight: 459.46
Update Date: 2026-04-22 18:57:36

What is LAS191859?

Description

LAS191859 is a CRTH2/DP2 antagonist with IC50 values of 9.58, 14, 15.5, and 7.6 nM for recombinant human, rat, mouse, and guinea pig CRTH2/DP2 receptors, respectively. In vitro evidence in GTPγS binding studies indicate that LAS191859 is a CRTh2 antagonist with activity in the low nanomolar range. This potency is also maintained in cellular assays performed with human eosinophils and whole blood. The main differentiation of LAS191859 vs other CRTh2 antagonists is in its receptor binding kinetics. LAS191859 has a residence time half-life of 21h at CRTh2 that translates into a long-lasting in vivo efficacy that is independent of plasma levels

Properties of LAS191859

storage temp.	Store at -20°C
solubility	DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml; Ethanol: 2.5 mg/ml
form	A crystalline solid

Safety information for LAS191859

Computed Descriptors for LAS191859

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