L-SEPIAPTERIN

Chemical properties

yellow to orange powder

The Uses of L-SEPIAPTERIN

L-Sepiapterin serves as a substrate for BH4 synthesis via the pterin salvage pathway. It inhibits rat liver GTP cyclohydrolase with an IC50 value of approximately 25 μM. It can be used to circumvent the inhibition of pterin biosynthesis by 2,4-diamino-6-hydroxy pyrimidine.[Cayman Chemical]

The Uses of L-SEPIAPTERIN

Sepiapterin improved the endothelial dysfunction in SMA from db?/db mice by decreasing oxidative stress. Sepiapterin is commonly used in the study for treamtment of Type I Diabetes

The Uses of L-SEPIAPTERIN

Sepiapterin can be used to induce sequence-specific photolesions in double-stranded DNA.

What are the applications of Application

An intermediate in the salvage pathway of tetrahydrobiopterin

Definition

ChEBI: L-sepiapterin is a sepiapterin with L configuration.

General Description

Sepiapterin, a pteridine derivative, is a stable precursor of tetrahydrobiopterin (BH₄). It is a yellow pigment found in sepia mutant of Drosophila melanogaster and lemon Bombyx mori mutant (silkworm).

Biochem/physiol Actions

Cofactor of nitric oxide synthase; intracellularly converted to tetrahydro-biopterin leading to the stimulation of nitric oxide.