L-Lactic dehydrogenase
Synonym(s):LAD;Lactate;LDH;LD;L-Lactate Dehydrogenase
- CAS NO.：9001-60-9
- Empirical Formula: NULL
- Molecular Weight: 0
- MDL number: MFCD00131466
- EINECS: 232-617-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-07-20 17:44:43
What is L-Lactic dehydrogenase?
The Uses of L-Lactic dehydrogenase
L-Lactic dehydrogenase is used in the determination of pyruvate (used in conjunction with reduced coenzyme) and in the diagnosis of myocardial infarction and leukemia.
The Uses of L-Lactic dehydrogenase
L-Lactic Dehydrogenase from bovine heart has been used as a standard in cytotoxicity assay. It has also been used in glutamic pyruvic transaminase (GPT) assay.
The Uses of L-Lactic dehydrogenase
L-Lactic Dehydrogenase from bovine heart has been used in ATPase assay of R2 complex Rvb1p-Rvb2p, RecA protein and sarcoplasmic reticulum Ca2+-ATPase (SERCA).
General Description
L-lactate dehydrogenase (LDH) is an enzyme that catalyzes the conversion of lactate to pyruvate.?In particular, lactic dehydrogenase A (LDHA) is mainly found in skeletal muscle, and for that reason is known as the M subunit. This recombinant form of LDHA has a C-terminal histidine-tag.
The gene LDHA (L-lactate dehydrogenase A chain) is mapped to human chromosome 11p15. It is a subunit of lactate dehydrogenase.
Biochem/physiol Actions
Also catalyzes the oxidation of other L-2-hydroxymonocarboxylic acids.
Purification Methods
A forty-fold purification of the dehydrogenase is effected by affinity chromatography using Sepharose 4B coupled to 8-(6-aminohexyl)amino-5'-AMP or -NAD . [Lees et al. Arch Biochem Biophys 163 561 1974, Pesce et al. J Biol Chem 239 1753 1964.]
Properties of L-Lactic dehydrogenase
| storage temp. | 2-8°C |
| form | suspension |
| color | white |
| Merck | 13,5349 |
| CAS DataBase Reference | 9001-60-9 |
| EPA Substance Registry System | Dehydrogenase, lactate (9001-60-9) |
Safety information for L-Lactic dehydrogenase
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for L-Lactic dehydrogenase
L-Lactic dehydrogenase manufacturer
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