L-DIHYDROOROTIC ACID
Synonym(s):L -Hydroorotic acid;2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid;Dihydro-L -orotic acid
- CAS NO.：5988-19-2
- Empirical Formula: C5H6N2O4
- Molecular Weight: 158.11
- MDL number: MFCD00085339
- EINECS: 624-952-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:13:01
What is L-DIHYDROOROTIC ACID?
Chemical properties
White to off-white crystalline powder
The Uses of L-DIHYDROOROTIC ACID
L-Dihydroorotic acid a metabolite.
What are the applications of Application
L-Dihydroorotic acid is a metabolite
Definition
ChEBI: (S)-dihydroorotic acid is the (S)-enantiomer of dihydroorotic acid that is an intermediate in the metabolism of pyridine. It has a role as a Saccharomyces cerevisiae metabolite, a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a conjugate acid of a (S)-dihydroorotate. It is an enantiomer of a (R)-dihydroorotic acid.
Biochem/physiol Actions
L-Dihydroorotic acid (DHO) serves as a substrate for dihydroorotate dehydrogenase (DHODH), an enzyme in the de novo synthesis of pyrimidine. Inhibition of DHOH by its inhibitors causes a large accumulation of upstream metabolite DHO and a reduction in the uridine levels. Therefore, DHO and uridine can be used as biomarkers for pyrimidine synthesis for the clinical development of DHOH inhibitors.
Properties of L-DIHYDROOROTIC ACID
| Melting point: | 254-255 °C (dec.)(lit.) |
| Boiling point: | 283.16°C (rough estimate) |
| Density | 1.523 |
| refractive index | 1.5090 (estimate) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMSO (Slightly), Water (Slightly, Heated, Sonicated) |
| form | Powder |
| pka | 2.82±0.20(Predicted) |
| color | White to off-white |
| Water Solubility | Soluble in water (partly), and dimethyl formamide. |
| CAS DataBase Reference | 5988-19-2(CAS DataBase Reference) |
| NIST Chemistry Reference | Orotic acid, dihydro-, l-(5988-19-2) |
Safety information for L-DIHYDROOROTIC ACID
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for L-DIHYDROOROTIC ACID
| InChIKey | UFIVEPVSAGBUSI-REOHCLBHSA-N |
New Products
Cyclopentane-1,2-dione 2,6-Dibromoaniline (4-Bromophenyl)(3-methoxyphenyl)methanone 4,5,7-Trimethyl-2(1H)-quinolinone 4-(6-HYDROXYHEXYLOXY)BENZOIC ACID 4-Hydroxy-6-methyl-1-(4-methylphenyl)-2naphthalenecarboxylic acid 2,6-Piperidinedione, 3-hydroxy-1-[(4-methoxyphenyl)methyl]- NA Cefuroxime EP Impurity-A N-Nitroso hydroxy Cetrizine EP Impurity-A Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity Lantanoprost rc B Clidinium Bromide Impurity 4 - fluoro- 2 - methoxy- 5 - nitroaniline 1-(2-amino-5-hydroxy phenyl)propan-1-one tert-butyl 4-(6-((7-cyclo pentyl -6-(dimethyl carbamoyl) -7H-pyrrolo [2,3-d]pyrimidin-2-yl) amino)pyridin-3-yl) piperazine-1-carboxylate (4-Fluoro-2-methoxy-5-nitro- phenyl)-[4- (1-methyl-1H- indol-3- yl)-pyrimidin-2-yl]- amine (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3- amine 5-bromo-2-chloro-N- cyclopentylpyrimidin-4- amine 2-Chloro Benzylcyanide 3,4 Diethoxy Benzylcyanide 3-chlorobenzyl cyanide 3,4 Dimethoxy BenzylcyanideRelated products of tetrahydrofuran
![L-4,5-DIHYDROOROTIC ACID, [2-14C]-](https://img.chemicalbook.in/StructureFile/ChemBookStructure4/GIF/CB3767465.gif)
![DIHYDROOROTIC ACID, [5,6-3H]](https://img.chemicalbook.in/StructureFile/ChemBookStructure3/GIF/CB5120691.gif)
You may like
-
L-Dihydroorotic acid 98% (HPLC) CAS 5988-19-2View Details
5988-19-2 -
L-Dihydroorotic acid CAS 5988-19-2View Details
5988-19-2 -
4-Hydroxy-6-methyl-1-(4-methylphenyl)-2naphthalenecarboxylic acid 98+View Details
101894-09-1 -
4-(6-HYDROXYHEXYLOXY)BENZOIC ACID 83883-25-4 98+View Details
83883-25-4 -
39973-47-2 NA 98+View Details
39973-47-2 -
2357109-89-6 98+View Details
2357109-89-6 -
39973-47-2 NA 98+View Details
39973-47-2 -
2357109-89-6 98+View Details
2357109-89-6
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.