L-Arginine L-glutamate

Originator

Modamate,Abbott,US,1960

The Uses of L-Arginine L-glutamate

L-Arginine L-Glutamate is used in the making of solution of arginine glutamate for the healing of radiation-induced skin ulcers in guinea pigs

The Uses of L-Arginine L-glutamate

Intravenous ammonia detoxicant in cases of liver failure.

Definition

ChEBI: Arginine glutamate is a glutamic acid derivative.

Manufacturing Process

This salt may be prepared by mixing L-arginine with L-glutamic acid in water and crystallizing the resulting salt from the water by the addition of a polar water miscible organic solvent to the water. For instance, when 17.2 g of Larginine and 14.5 g of L-glutamic acid were dissolved in 155 g of water, a clear homogeneous solution resulted which had a pH of 5.3. This solution was filtered and the filtrate was evaporated at 50°C under reduced pressure to a solution having a solids content of about 45%. Absolute methanol (220 g) was added to the concentrated solution of the salt and this mixture cooled to 5°C for one hour. The resulting solid salt was removed from the mixture by filtration and washed with absolute methanol. After being dried preliminarily in the air, the salt was further dried in a vacuum oven at 60°C for 3 hours. The resulting salt, L-arginine-L-glutamate, weighed 30 g (94.6% of the theoretically possible yield based on the amount of L-arginine and L-glutamic acid employed) and melted at 193-194.5°C with decomposition.

brand name

Modumate (Abbott).

Therapeutic Function

Ammonia detoxicant (hepatic failure)

General Description

White powder.

Air & Water Reactions

Slightly soluble in water.

Reactivity Profile

A dipeptide; hence an amide.

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition L-Arginine L-glutamate emits toxic fumes.