L-Alaninamide,N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-[(2,6-dichlorobenzoyl)oxy]-1-(2-ethoxy-2-oxoethyl)-2-oxopropyl]-(9CI)

CAS NO.：161511-45-1
Empirical Formula: C30H35Cl2N3O9
Molecular Weight: 652.52
Update Date: 2025-12-04 14:24:59

What is L-Alaninamide,N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-[(2,6-dichlorobenzoyl)oxy]-1-(2-ethoxy-2-oxoethyl)-2-oxopropyl]-(9CI)?

Biological Activity

SDZ 224-015 is an orally active inhibitor of the interleukin-1 beta (IL-1β) converting enzyme and caspase-1. SDZ 224-015 possesses anti-COVID-19 activity, targeting Mpro (IC50 of 30 nM)[1][2]. SDZ 224-015 (0.3-300 μg/kg) potently reduces carrageenin-induced paw oedema[2].SDZ 224-015 (0.2-5 mg/kg, p.o.) displays analgesic activity in the Randall-Selitto yeast-inflamed paw pressure test, significant at a dose of 1 mg/kg[2].

References

[1]. Martin A Redhead, et al. Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19. Sci Rep. 2021 Jun 24;11(1):13208. [2]. P R Elford, et al. Reduction of inflammation and pyrexia in the rat by oral administration of SDZ 224-015, an inhibitor of the interleukin-1 beta converting enzyme. Br J Pharmacol. 1995 Jun;115(4):601-6.

Properties of L-Alaninamide,N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-[(2,6-dichlorobenzoyl)oxy]-1-(2-ethoxy-2-oxoethyl)-2-oxopropyl]-(9CI)

Boiling point:	861.9±65.0 °C(Predicted)
Density	1.299±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
pka	11.05±0.46(Predicted)
form	Solid
color	White to off-white

Safety information for L-Alaninamide,N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-[(2,6-dichlorobenzoyl)oxy]-1-(2-ethoxy-2-oxoethyl)-2-oxopropyl]-(9CI)

Computed Descriptors for L-Alaninamide,N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-[(2,6-dichlorobenzoyl)oxy]-1-(2-ethoxy-2-oxoethyl)-2-oxopropyl]-(9CI)

New Products

Methyl 2-hydroxy-3-nitrobenzoate 1,3-Diethyl-1,3-Diphenylurea 2,4-dihydroxybenzaldehyde 3-(4-morpholinophenylamino)-5-amino-1H-pyrazole-4-carbonitrile Methyl 2-methylquinoline-6-carboxylate 2-((4-morpholinophenylamino) (methylthio) methylene) malononitrile 1,3-Di Iodo Benzene Methyl 2-oxo-2,3-dihydrobenzo[d]oxazole-7-carboxylate 4-(2-Aminoethyl)-7-hydroxy-2H-chromoen-2-one 3-Hydroxy-4-nitrobromobenzene 2-Ethyl-1,4-diaminobenzene 2-Ethylhexyl 4-aminobenzoate Thio Acetamide

Related products of tetrahydrofuran

Z-VAL-ALA-ASN-AMC

Z-VAL-VAL-ARG-AMC

Z-VRPR-FMK (trifluoroacetate salt)

Z-VAL-LYS-LYS-ARG-AFC

Z-TYR-VAL-ALA-ASP-CHLOROMETHYLKETONE

BENZYLOXYCARBONYL-L-VALYL-L-LYSYL-L-METHIONINE 4-METHYLCOUMARYL-7-AMIDE HYDROCHLORIDE

Z-VAL-ALA-ASP-AMC

UROKINASE SUBSTRATE I, COLORIMETRIC