L-838417
Synonym(s):3-(2,5-Difluorophenyl)-7-(1,1-dimethylethyl)-6-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-b]pyridazine
- CAS NO.：286456-42-6
- Empirical Formula: C19H19F2N7O
- Molecular Weight: 399.4
- MDL number: MFCD08690609
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-21 10:31:43
What is L-838417 ?
Chemical properties
White to Off-White Solid
The Uses of L-838417
A selective ligand for GABAA receptors
The Uses of L-838417
L-838417 is an anxiolytic agent and a selective GABAA receptor partial agonist that selectively binds to α1, α2, α3 and α5 subunits (1,2). It also exhibits antinociceptive and anti-inflammatory properties.
What are the applications of Application
L-838417 is a subtype-selective GABAA receptor partial agonist
Biological Activity
Subtype-selective GABA A receptor partial agonist. Selectively binds to α 1, α 2, α 3 and α 5 subunits (K i values are 0.79, 0.67, 0.67 and 2.25 nM respectively) but displays no efficacy at α 1 ( α 1-sparing). Exhibits non-sedative anxiolytic, antinociceptive and anti-inflammatory activity in vivo .
Storage
Store at +4°C
Properties of L-838417
| Melting point: | 196-198°C |
| Density | 1.40±0.1 g/cm3(Predicted) |
| storage temp. | Store at +4°C |
| solubility | DMSO: ≥20mg/mL |
| pka | 2.13±0.10(Predicted) |
| form | powder |
| color | white to off-white |
Safety information for L-838417
Computed Descriptors for L-838417
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![(2-METHYL-2H-[1,2,4]TRIAZOL-3-YL)-METHANOL](https://img.chemicalbook.in/CAS/GIF/91616-36-3.gif)
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