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Home Product name listL-759,633

L-759,633

CAS NO.：174627-50-0
Empirical Formula: C26H40O2
Molecular Weight: 384.59
MDL number: MFCD05662266
SAFETY DATA SHEET (SDS)
Update Date: 2026-11-04 16:53:25

L-759,633 Structural

What is L-759,633?

Description

L-759,633 is a high-affinity peripheral cannabinoid receptor (CB₂)-selective agonist with K_i values of 6.4 and 1,043 nM for CB₂ and central cannabinoid (CB₁) receptors, respectively. L-759,633 inhibits forskolin-stimulated cyclic AMP production in CHO cells transfected with CB₂ or CB₁ receptors with IC₅₀ values of 8.1 nM and 10 μM, respectively.

The Uses of L-759,633

L 759633 is a cannabinoid receptor (CB2) selective agonist and a structural analogues of ??9-Tetrahydro Cannabinol, an active constituent of cannabis. L 759633 has analgesic and anti-inflammatory properties.

What are the applications of Application

L-759633 is a high affinity and selective CB2 receptor agonist

Definition

ChEBI: 6h-dibenzo[b,d]pyran, 3-(1,1-dimethylheptyl)-6a,7,10,10a-tetrahydro-1-methoxy-6,6,9-trimethyl-, (6ar,10ar)- is a 1-benzopyran.

Biological Activity

High affinity, selective CB 2 receptor agonist (K i values are 6.4 and 1043 nM for CB 2 and CB 1 receptors respectively). Potently inhibits forskolin-stimulated cAMP production via CB 2 receptors expressed in CHO cells (EC 50 = 8.1 nM).

Properties of L-759,633

Boiling point:	447.9±45.0 °C(Predicted)
Density	0.956±0.06 g/cm3(Predicted)
storage temp.	Store at +4°C
solubility	Ethanol:20.0(Max Conc. mg/mL);52.0(Max Conc. mM) PBS (pH 7.2):0.25(Max Conc. mg/mL);0.65(Max Conc. mM)

Safety information for L-759,633

Computed Descriptors for L-759,633

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L-759,633

DELTA-8-THC

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