L-4,4'-BIPHENYLALANINE

CAS NO.：155760-02-4
Empirical Formula: C15H15NO2
Molecular Weight: 241.29
MDL number: MFCD01318878
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 06:19:52

What is L-4,4'-BIPHENYLALANINE?

Description

4-Biphenylyl-L-alanine (BipA) is a synthetic amino acid that was prepared to put a?“leash” on genetically modified?Escherichia coli.?It replaces phenylalanine in the codon of unmodified?E. coli. Additional phenylalanine derivatives have been made for the same purpose.
G. M. Church at Harvard Medical School and F. J. Isaacs at Yale University are using?E. coli?as a model to explore ways to prevent genetically modified organisms (GMOs) from reproducing in the environment. Tagging a GMO with a non-natural amino acid such as BipA allows it to reproduce in the laboratory but not in nature. If this strategy is successful, the next step would be to extend it to commercial GMOs such as crop plants.

The Uses of L-4,4'-BIPHENYLALANINE

L-4,4''-Biphenylalanine is a useful reagent in the preparation of other biologically active small molecules.

Properties of L-4,4'-BIPHENYLALANINE

Melting point:	227° - 229°C
Boiling point:	428.6±40.0 °C(Predicted)
Density	1.190±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	Acidic DMSO (Slightly)
form	Solid
pka	2.21±0.10(Predicted)
color	White to Off-White
Stability:	Hygroscopic
CAS DataBase Reference	155760-02-4(CAS DataBase Reference)

Safety information for L-4,4'-BIPHENYLALANINE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.