L-4-Fluorophenylalanine
- CAS NO.：1132-68-9
- Empirical Formula: C9H10FNO2
- Molecular Weight: 183.18
- MDL number: MFCD00063064
- EINECS: 145-896-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 02:01:01
What is L-4-Fluorophenylalanine?
Chemical properties
white to off-white powder
The Uses of L-4-Fluorophenylalanine
4-Fluoro-L-phenylalanine is a substrate for tyrosine hydroxylase (TH) that has been used to study the regulation of that enzyme.
What are the applications of Application
L-4-Fluoro-phenyl-alanine is a TH substrate which appears to inhibit mitosis and arrest cells in G2
Definition
ChEBI: A L-phenylalanine derivative that is L-phenylalanine in which the hydrogen at position 4 on the benzene ring is replaced by a fluoro group.
Purification Methods
It is recrystallised from aqueous EtOH. The (R)-N-acetyl derivative has m 142-145o, [] D -38.6o (c 8, EtOH). [Bennett & Nieman J Am Chem Soc 72 1800 1950, Beilstein 14 III 1268.]
Properties of L-4-Fluorophenylalanine
| Melting point: | ~255 °C (dec.) |
| Boiling point: | 313.3±32.0 °C(Predicted) |
| alpha | -26.5 º (c=1, H2O 25 ºC) |
| Density | 1.1939 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| form | powder to crystal |
| pka | 2.20±0.10(Predicted) |
| color | White to Almost white |
| Water Solubility | Soluble in water and 0.5M HCl (50 mg/ml). |
| BRN | 2416148 |
| CAS DataBase Reference | 1132-68-9(CAS DataBase Reference) |
Safety information for L-4-Fluorophenylalanine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for L-4-Fluorophenylalanine
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