L-4-Chlorophenylalanine
Synonym(s):L -PCPA
- CAS NO.：14173-39-8
- Empirical Formula: C9H10ClNO2
- Molecular Weight: 199.63
- MDL number: MFCD00063065
- EINECS: 238-023-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-12-03 18:03:33
What is L-4-Chlorophenylalanine?
Chemical properties
white powder
The Uses of L-4-Chlorophenylalanine
4-Chloro-L-phenylalanine is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals.
Definition
ChEBI: A non-proteinogenic L-alpha-amino acid that is L-phenylalanine in which the meta-hydrogen of the phenyl group has been replaced by a chlorine.
Biochem/physiol Actions
4-Chloro-L-phenylalanine (L-PCPA) inhibits the synthesis of 5-hydroxytryptamine (5-HT). 4-Chloro-DL-phenylalanine (PCPA) depletes the serotonin levels in the brain by its inhibitory effect on tryptophan hydroxylase (Tph). Studies support the protective effects of PCPA against monocrotaline-induced pulmonary vascular remodeling as well as in lung inflammation.
Properties of L-4-Chlorophenylalanine
| Melting point: | 263 °C (dec.)(lit.) |
| Boiling point: | 339.5±32.0 °C(Predicted) |
| alpha | -27 º (c=0.5, H2O 34 ºC) |
| Density | 1.2409 (rough estimate) |
| refractive index | 1.5790 (estimate) |
| storage temp. | -20°C |
| solubility | Aqueous Base (Slightly), Water (Slightly) |
| form | Powder |
| pka | 2.18±0.10(Predicted) |
| color | White |
| Water Solubility | Soluble in acetic acid. Slightly soluble in water. |
| BRN | 2416150 |
| CAS DataBase Reference | 14173-39-8(CAS DataBase Reference) |
Safety information for L-4-Chlorophenylalanine
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral H317:Sensitisation, Skin |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see … on this label). P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P405:Store locked up. |
Computed Descriptors for L-4-Chlorophenylalanine
| InChIKey | NIGWMJHCCYYCSF-QMMMGPOBSA-N |
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