KU 60019

CAS NO.：925701-46-8
Empirical Formula: C30H33N3O5S
Molecular Weight: 547.67
MDL number: MFCD18384974
SAFETY DATA SHEET (SDS)
Update Date: 2026-01-27 08:46:37

What is KU 60019?

Description

Ataxia-telangiectasia mutated (ATM) is a serine/threonine kinase that activates checkpoint signaling following double strand DNA breaks and genotoxic stress. Ku-60019 is a potent, reversible inhibitor of ATM kinase (IC₅₀ = 6.3 nM), blocking the phosphorylation of ATM substrate proteins. It is much less effective or without effect against a panel of 229 other kinases. Ku-60019 sensitizes glioma cells to radiation and inhibits migration and invasion of glioma cells in vitro. It produces radiosensitization and increases survival in vivo when administered intra-tumorally in orthotopic xenograft models of glioblastoma multiforme. Ku-60019 is particularly effective in producing lethality in cells with mutant p53 or that are deficient in PTEN.

The Uses of KU 60019

KU-60019 is a potent and reversible inhibitor of ATM kinase, blocking the phosphorylation of ATM substrate proteins. It sensitizes glioma cells to radiation and inhibits migration and invasion of glioma cells in vitro.

What are the applications of Application

KU 60019 is an ATM kinase inhibitor

Properties of KU 60019

Boiling point:	786.6±60.0 °C(Predicted)
Density	1.314±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.	Store at -20°C
solubility	DMF:20.0(Max Conc. mg/mL);36.52(Max Conc. mM) DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);0.91(Max Conc. mM) DMSO:75.0(Max Conc. mg/mL);136.94(Max Conc. mM) Ethanol:50.0(Max Conc. mg/mL);91.3(Max Conc. mM)
form	A crystalline solid
pka	13.52±0.20(Predicted)
color	Light yellow to khaki

Safety information for KU 60019

Computed Descriptors for KU 60019

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