KRAS G12C inhibitor 5

CAS NO.：2158297-63-1
Empirical Formula: C32H37N7O2
Molecular Weight: 551.68
MDL number: MFCD31813717
Update Date: 2026-01-05 11:31:08

What is KRAS G12C inhibitor 5?

Description

KRAS G12C inhibitor 5 is a KRas G12C inhibitor extracted from patent WO2017201161A1, Compound example 147[1].

Kirsten Rat Sarcoma 2 Viral Oncogene Homolog (KRas) is a small GTPase and a member of the Ras family of oncogenes. KRas serves a molecular switch cycling between inactive (GDP -bound) and active (GTP -bound) states to transduce upstream cellular signals received from multiple tyrosine kinases to downstream effectors to regulate a wide variety of processes, including cellular proliferation[1].

References

[1]. John P. Fischer, et al. Kras g12c inhibitors. WO2017201161A1.

Properties of KRAS G12C inhibitor 5

Boiling point:	838.6±75.0 °C(Predicted)
Density	1.228±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Soluble in DMSO
pka	9.31±0.40(Predicted)

Safety information for KRAS G12C inhibitor 5

Computed Descriptors for KRAS G12C inhibitor 5

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