kopsine

CAS NO.：559-48-8
Empirical Formula: C22H24N2O4
Molecular Weight: 380.44
Update Date: 2025-04-17 18:22:24

What is kopsine?

Description

The major constituent of Kopsia !ruticosa, this base has [α]_D - 17.5° (c 2.15, CHC13). It forms a series of crystalline salts and derivatives, e.g. the aurichloride, m.p. 203-5°C (dec.); perchlorate, m.p. 284°C (dec.); picrate, m.p. 230°C (dec.) and methiodide, m.p. 200°C (dec.). It may be reduced to the dihydro derivative which has m.p. 218°C. When fused with NaOH the alkaloid furnishes 2- methylindole and 2-indole-2-carboxylic acid.

References

Bhattacharya et al., 1. Amer. Chem. Soc., 71,3370 (1949)
Spiteller et al., Naturwiss., 49, 279 (1962)
Govindachari et al., Helv. Chim. Acta, 45, 1146 (1962)
Govindachari et al., ibid, 46, 433, 572 (1963)
Battersby, Gregory.,J. Chern. Soc., 22 (1963)

Properties of kopsine

Melting point:	220°C (dec.).
alpha	D27 -14.3 ± 1° (c = 2 in chloroform)

Safety information for kopsine

Computed Descriptors for kopsine

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