KN93 hydrochloride

CAS NO.：1956426-56-4
Empirical Formula: C26H30Cl2N2O4S
Molecular Weight: 537.5
MDL number: MFCD27992054
Update Date: 2026-01-05 11:31:08

What is KN93 hydrochloride?

Biological Activity

KN93 hydrochloride is a cell-permeable, reversible and competitive inhibitor of calmodulin-dependent kinase type II (CaMKII) with Ki of 370 nM.

in vitro

After 2 days of KN-93 treatment, 95% of cells are arrested in G1. G1 arrest is reversible; 1 day after KN93 release, a peak of cells had progressed into S and G2-M. KN93 also blocks cell growth stimulated by basic fibroblast growth factor, platelet-derived growth factor-BB, and epidermal growth factor in NIH 3T3 fibroblasts.

Properties of KN93 hydrochloride

storage temp.	Store at -20°C
solubility	DMF:10.0(Max Conc. mg/mL);18.6(Max Conc. mM) DMSO:20.5(Max Conc. mg/mL);38.14(Max Conc. mM) Water:0.45(Max Conc. mg/mL);0.84(Max Conc. mM)
form	A crystalline solid
color	White to off-white

Safety information for KN93 hydrochloride

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention.

Computed Descriptors for KN93 hydrochloride

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