KLH45

CAS NO.：1632236-44-2
Empirical Formula: C24H25F3N4O2
Molecular Weight: 458.48
MDL number: MFCD30742935
Update Date: 2025-12-07 19:09:50

What is KLH45?

Description

KLH45 is an inhibitor of the phospholipase DDHD domain containing 2 (DDHD2; IC₅₀ = 1.3 nM). It is selective for DDHD2 over greater than 50 serine hydrolases, including DDHD1 and Sec23ip, but does inhibit α/β-hydrolase domain-containing protein 6 (ABHD6). It inhibits DDHD2 and ABHD6 in Neuro2A cells when used at a concentration of less than 10 nM and inhibits DDHD2 by greater than 95% at a concentration of 25 nM. KLH45 (2 μM) prevents increases in triacylglycerol (TAG) hydrolase activity in HEK293T cell lysates expressing recombinant DDHD2 and incubated with a radiolabeled TAG substrate. It decreases TAG levels in the CNS of mice when administered at a dose of 20 mg/kg twice per day for four days. KLH45 (2 μM) also reverses DDHD2-induced lipid droplet reduction in COS-7 cells expressing recombinant DDHD2 and loaded with oleic acid.

The Uses of KLH45

KLH45 is a novel selective inhibitor of DDHD2.

Properties of KLH45

Boiling point:	561.0±60.0 °C(Predicted)
Density	1.29±0.1 g/cm3(Predicted)
solubility	DMSO:30.0(Max Conc. mg/mL);65.43(Max Conc. mM) Ethanol:30.0(Max Conc. mg/mL);65.43(Max Conc. mM)
form	Solid-Liquid Mixture
pka	-1.76±0.20(Predicted)
color	Off-white to light yellow

Safety information for KLH45

Computed Descriptors for KLH45

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